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<p>The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among <i>H.&#xa0;influenzae</i> was observed in some Asian countries. Herein, we reported the first XDR&#xa0;<i>H. influenzae</i>&#xa0;isolated in Geneva, Switzerland. This strain was isolated in&#xa0;a good-quality&#xa0;sputum sample from a 63&#xa0;year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.</p>

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Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland

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  • 发表日期：

    2025年3月6日

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  • Abdessalam Cherkaoui,
  • Patrice Francois,
  • Nadia Gaia,
  • Gesuele Renzi,
  • Adrien Fischer,
  • Jacques Schrenzel

摘要

The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among H. influenzae was observed in some Asian countries. Herein, we reported the first XDR H. influenzae isolated in Geneva, Switzerland. This strain was isolated in a good-quality sputum sample from a 63 year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.