Rectal colonization with multidrug-resistant organisms and risk for bloodstream infection among high-risk Greek patients

期刊论文
发表日期：

2024年11月21日

查看全文

Polyxeni Karakosta,
Georgios Meletis,
Elisavet Kousouli,
Efthymia Protonotariou,
Aikaterini Tarpatzi,
Sophia Vourli,
Panagiota Christina Georgiou,
Vasiliki Mamali,
Lemonia Skoura,
Olympia Zarkotou,
Spyros Pournaras

摘要

Background

Studies link multidrug-resistant organism (MDRO) rectal colonization to increased infection risk, data from Greece, a country with high rates of MDRO, are limited.

Methods

We assessed bloodstream infection (BSI) risk following rectal colonization by MDROs across three Greek hospitals (2019–2022).

Results

Of 4,370 inpatients, 31.1% were colonized by carbapenem-resistant Enterobacterales (CRE), 30.1% carbapenem-resistant Acinetobacter baumannii (CRAB), 5.8% carbapenem-resistant Pseudomonas aeruginosa (CRPA), 28.4% vancomycin-resistant enterococci (VRE). Subsequent BSI from the same MDRO species was developed in 15.6% of CRE, 19.7% of CRAB, 9.2% of CRPA and 3.5% of VRE carriers. Previous rectal colonization increases significantly MDRO BSI risk [RR (95%CI): CRE 5.2 (3.9–6.8), CRAB 2.7 (2.2–3.3), CRPA 9.6 (5.8–16.0), VRE 2.5 (1.5–4.2)].

Conclusion

Clinicians should consider MDRO carriage information for selecting empiric treatment.