Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature

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发表日期：

2024年5月16日

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Barthelemy Lafon-Desmurs,
Benoit Gachet,
Benjamin Hennart,
Benjamin Valentin,
Gabrielle Roosen,
Maxime Degrendel,
Caroline Loiez,
Eric Beltrand,
Piervito D’Elia,
Henri Migaud,
Olivier Robineau,
Eric Senneville

摘要

Implant-related infections may need suppressive antibiotic therapy (SAT). We describe a SAT strategy using dalbavancin with therapeutic drug monitoring (TDM). This is a retrospective bicentric study of patients with implant-related infection who received dalbavancin SAT between January 2021 and September 2023. Fifteen patients were included. Median number of injections was 4 (IQR: 2–7). Median time between two reinjections was 57 days (IQR 28–82). Dalbavancin plasma concentrations were above 4 mg/L for 97.9% of dosages (93/95) and above 8 mg/L for 85% (81/95). These results support the use of dalbavancin SAT for implant-related infections.