Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit

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发表日期：

2024年4月27日

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Emmanuel Dudoignon,
Francois Caméléna,
Matthieu Lafaurie,
Benjamin Deniau,
Maité Chaussard,
Maxime Coutrot,
Lucie Guillemet,
Alexandru Cupaciu,
Alexandre Pharaboz,
Louis Boutin,
Mourad Benyamina,
Marc Chaouat,
Maurice Mimoun,
Manel Merimèche,
Alexandre Mebazaa,
Benoit Plaud,
Béatrice Berçot,
François Dépret,
Guillaume Mellon

摘要

We present our findings on interpatient transmission, epidemic control measures, and the outcomes of a series of ten critically ill burn patients who were either colonized or infected with carbapenem-resistant Acinetobacter baumannii (CRAB). None of the five infected patients achieved clinical cure, and all experienced relapses. Microbiological failure was observed in 40% of the infected patients. The isolated CRAB strains were found to carry bla_OXA−23 and armA resistance genes. Despite the lack of clinical cure, all five infected patients survived and were discharged from the Burn Intensive Care Unit.