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Novel Providencia xianensis sp. nov.: A multidrug-resistant species identified in clinical infections

  • Xu Dong,
  • Yanghui Xiang,
  • Peihong Yang,
  • Shanmei Wang,
  • Wenjuan Yan,
  • Youhua Yuan,
  • Shan Zhou,
  • Ke Zhou,
  • Jiayun Liu,
  • Ying Zhang

摘要

Providencia genus is known to harbor certain opportunistic pathogens capable of causing human infections. Here, we report two strains of multidrug-resistant bacteria initially identified as Providencia rettgeri by mass spectrometry, but genome analysis revealed their ANI (79.84–84.20%) and dDDH (21.1–25.6%) values to fall below the accepted species threshold for known Providencia species. We therefore propose that these isolates be recognized as a novel species, Providencia xianensis sp. nov. Alarmingly, both strains, isolated from locations far apart, exhibited resistance to last-resort antibiotics, indicating their possible wide distribution, underscoring the urgency for immediate attention and enhanced surveillance for this emerging multidrug-resistant pathogen.