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<p>We report a case of muscular polyarteritis nodosa in a 23-year-old man with no past medical history presenting with diffuse myalgias, weight loss, fatigue, hypertension, and elevated C-reactive protein. Normal creatine kinase and electromyography contributed to a delayed diagnosis. MRI-guided muscular biopsy confirmed necrotizing vasculitis. Corticosteroid therapy led to rapid improvement.</p>

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Asymmetrical muscular disorder with normal creatine kinase (CK) and electromyography (EMG): the challenging diagnosis of muscular polyarteritis nodosa (MPAN), case report and literature review

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Alexandre Dib,
  • Hippolyte Lequain,
  • Tanguy Fenouil,
  • Antoine Pegat,
  • Philippe Petiot,
  • Andras Barta,
  • Charles Mayard,
  • Alessio Balletti,
  • Emilie Virot,
  • Isabela Pascu,
  • Arnaud Hot,
  • Laure Gallay

摘要

We report a case of muscular polyarteritis nodosa in a 23-year-old man with no past medical history presenting with diffuse myalgias, weight loss, fatigue, hypertension, and elevated C-reactive protein. Normal creatine kinase and electromyography contributed to a delayed diagnosis. MRI-guided muscular biopsy confirmed necrotizing vasculitis. Corticosteroid therapy led to rapid improvement.