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Background <p>Autoimmune encephalitis (AE) comprises a rare and heterogeneous group of immune-mediated disorders affecting the central nervous system, frequently characterized by both psychiatric and neurological symptoms. In pediatric populations, acute psychiatric manifestations, such as agitation, mood instability, and psychosis, may precede neurological signs, often complicating early diagnosis due to their overlap with primary psychiatric disorders. This retrospective observational study aimed to characterize the early psychiatric presentations of pediatric AE through the analysis of clinical records concerning inpatient admissions to a tertiary Child and Adolescent Neuropsychiatry Unit.</p> Materials and Methods <p>We screened 1,577 inpatient admissions for cases presenting with acute-onset psychiatric symptoms (July 2022–July 2024). Of 58 patients, 6 (mean age: 10.3 ± 5.2&#xa0;years; 4 males, 2 females) received a final diagnosis of definite or probable AE based on established pediatric guidelines, thus meeting our inclusion criteria.</p> Results <p>All patients presented with psychiatric symptoms, including externalizing behaviors (2/6), mood disturbances with psychotic features (4/6), and sleep disorders (4/6). All underwent comprehensive diagnostic evaluations, including cerebrospinal fluid (CSF) analysis, electroencephalography, and brain MRI. CSF biochemical abnormalities were detected in 5 out of 6 patients, while neuronal antibodies were identified in 4 out of 6 cases (two with anti-NMDAR and two with anti-GAD65 positivity, including one with both).</p> Conclusions <p>Our findings underscore the relevance of early psychiatric symptoms in pediatric AE and emphasize the importance of considering autoimmune etiologies in new-onset psychiatric presentations, particularly in the absence of prior psychiatric history.</p>

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Early psychiatric manifestations in pediatric autoimmune encephalitis: clinical data from a tertiary center

  • 期刊论文

  • 发表日期：

    2025年12月26日

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  • V. Baglioni,
  • L. Terenzi,
  • C. Corazzina,
  • D. Esposito,
  • I. Notaristefano,
  • F. Panvino,
  • G. Ricciardi,
  • S. Romano,
  • P. Papoff,
  • M. Mastrangelo,
  • F. Pisani

摘要

Background

Autoimmune encephalitis (AE) comprises a rare and heterogeneous group of immune-mediated disorders affecting the central nervous system, frequently characterized by both psychiatric and neurological symptoms. In pediatric populations, acute psychiatric manifestations, such as agitation, mood instability, and psychosis, may precede neurological signs, often complicating early diagnosis due to their overlap with primary psychiatric disorders. This retrospective observational study aimed to characterize the early psychiatric presentations of pediatric AE through the analysis of clinical records concerning inpatient admissions to a tertiary Child and Adolescent Neuropsychiatry Unit.

Materials and Methods

We screened 1,577 inpatient admissions for cases presenting with acute-onset psychiatric symptoms (July 2022–July 2024). Of 58 patients, 6 (mean age: 10.3 ± 5.2 years; 4 males, 2 females) received a final diagnosis of definite or probable AE based on established pediatric guidelines, thus meeting our inclusion criteria.

Results

All patients presented with psychiatric symptoms, including externalizing behaviors (2/6), mood disturbances with psychotic features (4/6), and sleep disorders (4/6). All underwent comprehensive diagnostic evaluations, including cerebrospinal fluid (CSF) analysis, electroencephalography, and brain MRI. CSF biochemical abnormalities were detected in 5 out of 6 patients, while neuronal antibodies were identified in 4 out of 6 cases (two with anti-NMDAR and two with anti-GAD65 positivity, including one with both).

Conclusions

Our findings underscore the relevance of early psychiatric symptoms in pediatric AE and emphasize the importance of considering autoimmune etiologies in new-onset psychiatric presentations, particularly in the absence of prior psychiatric history.