Scholarlink

Introduction <p>Autoimmune polyglandular syndromes (APS) encompass a broad spectrum of disorders. APS III is characterized by&#xa0;autoimmune thyroiditis (AT) plus any autoimmune disorder, excluding Addison's disease.</p> Methods and results <p>This study explores the link between GAD65 related-temporal lobe epilepsy (GAD-TLE) and APS III. We retrospectively analyzed 29 GAD-TLE patients. Eighteen patients (62%) experienced at least one autoimmune disease, and ten patients (56%) fulfilled diagnostic criteria for APS III. In addition to AT and GAD-TLE, five patients had type 1 diabetes mellitus, one patient had latent autoimmune diabetes in adulthood, one autoimmune alopecia, one pernicious anemia, one had celiac disease and one patient had autoimmune alopecia, vitiligo, autoimmune atrophic gastritis and psoriasis. Approximately 35 years after the onset of the first disease, the probability of having the second disorder is over 80%. In our cohort, GAD65 antibodies are more frequently linked to AT than to type 1 diabetes mellitus, despite their well-known association.</p> Conclusion <p>Our data suggests that GAD65-TLE may share a common pathophysiology and should be included among APS-III diagnostic criteria. These insights support the need for rigorous, multidisciplinary monitoring to prevent delays in diagnosis and treatment. This work enhances understanding of APS complexity and informs targeted management strategies for patients with&#xa0;overlapping endocrine and neurological autoimmune disorders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Autoimmune polyglandular syndrome and GAD65 related-temporal lobe epilepsy

  • 期刊论文

  • 发表日期：

    2025年6月26日

查看全文
  • Roberta Di Giacomo,
  • Valentina Gasparini,
  • Giulia Salvucci,
  • Chiara Pastori,
  • Andrea Stabile,
  • Giulia Battaglia,
  • Giuseppe Didato,
  • Annalisa Parente,
  • Rosalba Ferrario,
  • Francesca Andreetta,
  • Angelo Del Sole,
  • Flavio Villani,
  • Fabio Martino Doniselli,
  • Anna Paola Savoldi,
  • Marco de Curtis,
  • Francesco Deleo

摘要

Introduction

Autoimmune polyglandular syndromes (APS) encompass a broad spectrum of disorders. APS III is characterized by autoimmune thyroiditis (AT) plus any autoimmune disorder, excluding Addison's disease.

Methods and results

This study explores the link between GAD65 related-temporal lobe epilepsy (GAD-TLE) and APS III. We retrospectively analyzed 29 GAD-TLE patients. Eighteen patients (62%) experienced at least one autoimmune disease, and ten patients (56%) fulfilled diagnostic criteria for APS III. In addition to AT and GAD-TLE, five patients had type 1 diabetes mellitus, one patient had latent autoimmune diabetes in adulthood, one autoimmune alopecia, one pernicious anemia, one had celiac disease and one patient had autoimmune alopecia, vitiligo, autoimmune atrophic gastritis and psoriasis. Approximately 35 years after the onset of the first disease, the probability of having the second disorder is over 80%. In our cohort, GAD65 antibodies are more frequently linked to AT than to type 1 diabetes mellitus, despite their well-known association.

Conclusion

Our data suggests that GAD65-TLE may share a common pathophysiology and should be included among APS-III diagnostic criteria. These insights support the need for rigorous, multidisciplinary monitoring to prevent delays in diagnosis and treatment. This work enhances understanding of APS complexity and informs targeted management strategies for patients with overlapping endocrine and neurological autoimmune disorders.