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Background <p>Dengue virus (DENV) has emerged as a significant cause of neurological complications, including&#xa0;movement disorders, which fall under the broader category of neurological manifestations associated with DENV&#xa0;infection. These disorders can have serious implications for patient’s quality of life, especially in tropical and&#xa0;subtropical regions where dengue is endemic. The neurological complications of DENV, while less commonly&#xa0;recognized when compared to its classical features (like fever, haemorrhagic manifestations, or shock), are&#xa0;increasingly being reported thus warranting an exhaustive exploration.</p> Methods <p>We undertook a comprehensive and critical review to investigate the emerging link between movement&#xa0;disorders and DENV infections. An in depth and broad range search was performed across leading scientific&#xa0;databases (PubMed, Scopus, Embase and Google Scholar). We collected and analyzed a wide spectrum of relevant&#xa0;studies and case reports. This detailed methodology ensured a systematic and authoritative exploration of the&#xa0;neurological consequences associated with DENV, creating the foundation for deeper clinical insight and future&#xa0;research.</p> Results <p>The analysis encompassed 80 studies on movement disorders linked to DENV infections. These studies were&#xa0;thoroughly reviewed and critically evaluated, with the findings presented in an inclusive and investigative manner.&#xa0;</p> Conclusion <p>This narrative review provides a comprehensive analysis of movement disorders linked to DENV&#xa0;infections, enveloping their epidemiology, clinical features, neuropathogenesis, current therapeutic strategies, and&#xa0;outlining extensive directions for future research.</p>

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A comprehensive and critical narrative review on movement disorders linked through dengue virus based infection

  • 期刊论文

  • 发表日期：

    2025年6月14日

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  • Niraj Kumar Srivastava,
  • Nikhil Pandey,
  • Janki Makani,
  • Ibrahim Hussain,
  • Neetu Rani Dhiman,
  • Anand Kumar,
  • Deepika Joshi

摘要

Background

Dengue virus (DENV) has emerged as a significant cause of neurological complications, including movement disorders, which fall under the broader category of neurological manifestations associated with DENV infection. These disorders can have serious implications for patient’s quality of life, especially in tropical and subtropical regions where dengue is endemic. The neurological complications of DENV, while less commonly recognized when compared to its classical features (like fever, haemorrhagic manifestations, or shock), are increasingly being reported thus warranting an exhaustive exploration.

Methods

We undertook a comprehensive and critical review to investigate the emerging link between movement disorders and DENV infections. An in depth and broad range search was performed across leading scientific databases (PubMed, Scopus, Embase and Google Scholar). We collected and analyzed a wide spectrum of relevant studies and case reports. This detailed methodology ensured a systematic and authoritative exploration of the neurological consequences associated with DENV, creating the foundation for deeper clinical insight and future research.

Results

The analysis encompassed 80 studies on movement disorders linked to DENV infections. These studies were thoroughly reviewed and critically evaluated, with the findings presented in an inclusive and investigative manner. 

Conclusion

This narrative review provides a comprehensive analysis of movement disorders linked to DENV infections, enveloping their epidemiology, clinical features, neuropathogenesis, current therapeutic strategies, and outlining extensive directions for future research.