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<p>This comprehensive review meticulously examines the pivotal and multifaceted role of G protein-coupled receptors (GPCRs) in the complex pathogenesis of Parkinson's disease (PD), a neurodegenerative disorder that profoundly impacts motor control and cognitive function. Initially, we introduce the fundamental concepts of GPCRs, delving into their intricate structures and diverse functions within the nervous system, highlighting their importance as key players in cellular communication and signal transduction. Following this foundational overview, we thoroughly analyze specific GPCRs that have been closely associated with the onset and progression of PD, exploring the intricate mechanisms by which they influence disease progression through the nuanced regulation of neurotransmitter release, complex signaling pathways, and crucial aspects of cell survival. Furthermore, we engage in a detailed discussion regarding the promising prospects of GPCRs as potential therapeutic targets for intervention in PD, emphasizing the significance of recent groundbreaking research findings that shed light on the therapeutic implications of modulating GPCR activity. Finally, drawing upon the latest advancements in research, we propose insightful directions for future studies, as well as a thoughtful consideration of the myriad challenges that lie ahead in this dynamic and rapidly evolving field of study, which holds the potential to enhance our understanding of PD and pave the way for innovative treatment strategies.&#xa0;&#xa0;</p> Graphical Abstract <p></p>

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The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease

  • 期刊论文

  • 发表日期：

    2025年6月11日

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  • Yajun Jing,
  • Peisen Yao,
  • Honglin Zhu,
  • Lianghong Yu,
  • Yuanxiang Lin,
  • Dezhi Kang

摘要

This comprehensive review meticulously examines the pivotal and multifaceted role of G protein-coupled receptors (GPCRs) in the complex pathogenesis of Parkinson's disease (PD), a neurodegenerative disorder that profoundly impacts motor control and cognitive function. Initially, we introduce the fundamental concepts of GPCRs, delving into their intricate structures and diverse functions within the nervous system, highlighting their importance as key players in cellular communication and signal transduction. Following this foundational overview, we thoroughly analyze specific GPCRs that have been closely associated with the onset and progression of PD, exploring the intricate mechanisms by which they influence disease progression through the nuanced regulation of neurotransmitter release, complex signaling pathways, and crucial aspects of cell survival. Furthermore, we engage in a detailed discussion regarding the promising prospects of GPCRs as potential therapeutic targets for intervention in PD, emphasizing the significance of recent groundbreaking research findings that shed light on the therapeutic implications of modulating GPCR activity. Finally, drawing upon the latest advancements in research, we propose insightful directions for future studies, as well as a thoughtful consideration of the myriad challenges that lie ahead in this dynamic and rapidly evolving field of study, which holds the potential to enhance our understanding of PD and pave the way for innovative treatment strategies.  

Graphical Abstract