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<p>The aim of this study is to describe the results of a comprehensive neurological assessment conducted on a cohort of 70 adults with Down syndrome (DS), aged 21 to 74 years, recruited in Bologna, Italy. Neurocognitive disorder (NcD) was identified in 28.6% of participants and showed a significant association with psychiatric disorders (<i>p</i>=0.03). Psychiatric conditions were present in 40% of the cohort, while Down Syndrome Regression Disorder (DSRD) was diagnosed in 7.1%. Transient loss of consciousness affected 28.6% of individuals. Epilepsy, observed in 7.1%, was significantly associated with NcD (<i>p</i>=0.02). Neurological examination revealed that stereotypic movements correlated with DSRD (<i>p</i>&lt;0.01), tics with obsessive-compulsive disorders (<i>p</i>=0.01), and hypokinetic movement disorders with psychotic conditions (<i>p</i>=0.03). Additionally, nystagmus and cerebellar signs were significantly associated with elevated serum bilirubin levels (<i>p</i>&lt;0.01). These findings underscore the high prevalence and complexity of neurological comorbidities in adults with DS, emphasizing the need for specialized, multidisciplinary care.</p>

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Neurological findings in a cohort of adults with down syndrome

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月13日

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  • Nicola Grotteschi,
  • Magali Jane Rochat,
  • Virginia Pollarini,
  • Alessandro Ghezzo,
  • Camilla Pellegrini,
  • Giovanna Calandra-Buonaura,
  • Raffaele Lodi,
  • Caterina Tonon,
  • Pietro Cortelli,
  • Maria Giulia Bacalini,
  • Gian Luca Pirazzoli,
  • Luisa Sambati

摘要

The aim of this study is to describe the results of a comprehensive neurological assessment conducted on a cohort of 70 adults with Down syndrome (DS), aged 21 to 74 years, recruited in Bologna, Italy. Neurocognitive disorder (NcD) was identified in 28.6% of participants and showed a significant association with psychiatric disorders (p=0.03). Psychiatric conditions were present in 40% of the cohort, while Down Syndrome Regression Disorder (DSRD) was diagnosed in 7.1%. Transient loss of consciousness affected 28.6% of individuals. Epilepsy, observed in 7.1%, was significantly associated with NcD (p=0.02). Neurological examination revealed that stereotypic movements correlated with DSRD (p<0.01), tics with obsessive-compulsive disorders (p=0.01), and hypokinetic movement disorders with psychotic conditions (p=0.03). Additionally, nystagmus and cerebellar signs were significantly associated with elevated serum bilirubin levels (p<0.01). These findings underscore the high prevalence and complexity of neurological comorbidities in adults with DS, emphasizing the need for specialized, multidisciplinary care.