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Background <p>Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by its aggressive nature. Its main clinical features include autonomic dysfunction, Parkinson’s disease, and cerebellar ataxia.</p> Methods <p>We conducted a comprehensive review of the existing literature, exploring studies and reports related to the mechanisms and treatment of multiple system atrophy related neurogenic bladder. Our aim is to provide a detailed and up-to-date overview of its underlying pathophysiology and current therapeutic strategies.</p> Results and Conclusion <p>Neurogenic bladder, a common manifestation of MSA, often goes untreated or mistreated, significantly affecting patients’ quality of life. Early-stage bladder dysfunction is frequent in MSA patients and correlates with disease severity. The mechanisms of MSA related neurogenic bladder are related to the autonomic nervous system, somatic nerves, frontal cortex, brainstem, and sacral medulla center. Currently, treatment for MSA related neurogenic bladder is mainly symptomatic, and specific drugs are lacking. Further in-depth research is needed to develop more effective therapeutic options that improve patients' quality of life and reduce the risk of complications.</p>

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Multiple system atrophy related neurogenic bladder: mechanism and treatment

  • 期刊论文

  • 发表日期：

    2025年1月29日

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  • Gengqing Ren,
  • Yao Wang,
  • Hao Tian,
  • Kaige Zhang,
  • Han Zhang,
  • Xiaoxu Liu,
  • Zhigang Chen

摘要

Background

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by its aggressive nature. Its main clinical features include autonomic dysfunction, Parkinson’s disease, and cerebellar ataxia.

Methods

We conducted a comprehensive review of the existing literature, exploring studies and reports related to the mechanisms and treatment of multiple system atrophy related neurogenic bladder. Our aim is to provide a detailed and up-to-date overview of its underlying pathophysiology and current therapeutic strategies.

Results and Conclusion

Neurogenic bladder, a common manifestation of MSA, often goes untreated or mistreated, significantly affecting patients’ quality of life. Early-stage bladder dysfunction is frequent in MSA patients and correlates with disease severity. The mechanisms of MSA related neurogenic bladder are related to the autonomic nervous system, somatic nerves, frontal cortex, brainstem, and sacral medulla center. Currently, treatment for MSA related neurogenic bladder is mainly symptomatic, and specific drugs are lacking. Further in-depth research is needed to develop more effective therapeutic options that improve patients' quality of life and reduce the risk of complications.