Distinctive sleep complaints and polysomnographic findings in antibody subgroups of autoimmune limbic encephalitis

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2024年6月24日

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Cem İsmail Küçükali,
Vuslat Yılmaz,
Derya Karadeniz,
Utku Oğan Akyıldız,
Demet İlhan Algın,
Ayşegül Şeyma Sarıtaş,
Ayşın Kısabay Ak,
Aylin Bican Demir,
Hikmet Yılmaz,
Füsun Mayda Domaç,
Ayşe Deniz Elmalı,
Ülkü Dübüş Hoş,
R. Gökçen Gözübatık-Çelik,
Vasfiye Kabeloğlu,
Bengisu Bilgin,
Deniz Tuncel Berktaş,
Bengi Gül Türk,
Şakir Delil,
Cengiz Dilber,
Sedef Terzioğlu Öztürk,
S. Naz Yeni,
Çiğdem Özkara,
Murat Aksu,
Erdem Tüzün,
Gülçin Benbir Şenel

摘要

Introduction

Sleep disturbances are being increasingly recognized in association with autoimmune encephalitis (AIE). We investigated the prevalence of sleep-related symptoms and polysomnographic features of patients with AIE and the long-term outcomes in these patients in a multi-center, prospective study from Turkey.

Methods

We prospectively evaluated patients with definite AIE in a common database including demographics, AIE-related and sleep-related symptomatology. Maximum and latest modified Rankin scores (mRS) and Liverpool Outcome Score (LOS) were noted.

Results

Of 142 patients, 87 patients (61.3%) fulfilled the criteria for definite AIE (mean age, 46.8+18.8 years; 51.7% women; mean disease duration, 21.0+38.4 months). 78.9% of patients had at least one or more new onset or worsened sleep-related symptomatology: insomnia (55.3%), excessive daytime sleepiness (EDS, 28.0%), sleep apnea (18.7%), REM sleep behavior disorder (RBD, 17.3%), restless legs syndrome (10.7%) and oneiric stupor (9.3%). Sleep efficiency, N3 and REM sleep were decreased and N1 sleep was increased in patients with Ab[+] AIE. LOS points were highest in those with insomnia and sleep apnea, and lowest in those with EDS, RBD and oneiric stupor. RBD and sleep apnea were more common in anti-LG1 Ab[+] group than anti-NMDAR Ab[+] group. Index of periodic leg movements was highest in anti-LG1 Ab[+] group. Patients with EDS and oneiric stupor had more common memory problems. Maximum and latest mRS scores were positively correlated with EDS and oneiric stupor. EDS, RBD and oneiric stupor were negatively correlated with LOS points.

Conclusion

Our study emphasizes the presence and importance of early diagnosis of sleep disturbances in AIE in regard to their deteriorative influences on disease prognosis.