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<p>With the increasing global population and climate-related challenges, the demand for sustainable and nutritious food has increased significantly. Biotechnology offers promising solutions through advanced genome-editing tools and cellular agriculture approaches that can improve food production, nutritional quality, and environmental sustainability. This review provides an integrated overview of major biotechnological advances, including CRISPR/Cas9, TALENs, zinc-finger nucleases, and cultured food technologies. In addition to summarizing recent developments, the review critically discusses the advantages, limitations, biosafety concerns, regulatory challenges, and commercialization potential of these technologies. Particular attention is given to off-target genome editing, scalability issues in cellular agriculture, consumer acceptance, and environmental trade-offs associated with large-scale applications. The review further highlights future priorities such as precision genome editing, sustainable bioprocessing, and improved regulatory frameworks. Overall, these technologies have strong potential to support sustainable food production and global food security; however, their successful implementation will require technological improvements, long-term safety assessment, and greater public trust.</p>

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Engineering the future of food: biotechnology, genome editing, and cellular agriculture for sustainable food production and security

  • 期刊论文

  • 发表日期：

    2026年7月31日

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  • Sakshi Raturi,
  • Swati Kumari,
  • Avinash Sharma,
  • Navin Kumar,
  • Dheeraj Shootha,
  • Yograj Bist

摘要

With the increasing global population and climate-related challenges, the demand for sustainable and nutritious food has increased significantly. Biotechnology offers promising solutions through advanced genome-editing tools and cellular agriculture approaches that can improve food production, nutritional quality, and environmental sustainability. This review provides an integrated overview of major biotechnological advances, including CRISPR/Cas9, TALENs, zinc-finger nucleases, and cultured food technologies. In addition to summarizing recent developments, the review critically discusses the advantages, limitations, biosafety concerns, regulatory challenges, and commercialization potential of these technologies. Particular attention is given to off-target genome editing, scalability issues in cellular agriculture, consumer acceptance, and environmental trade-offs associated with large-scale applications. The review further highlights future priorities such as precision genome editing, sustainable bioprocessing, and improved regulatory frameworks. Overall, these technologies have strong potential to support sustainable food production and global food security; however, their successful implementation will require technological improvements, long-term safety assessment, and greater public trust.