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<p>A single-center in vitro study was performed using 50 clinically-derived <i>Pseudomonas aeruginosa</i> isolates to evaluate the antimicrobial, antibiofilm, and modulation of quorum sensing (QS)-related phenotypes of a fermented sausage-originated <i>Latilactobacillus sakei</i> postbiotic. A total of 50 antibiotic-resistant clinical <i>P. aeruginosa</i> isolates were evaluated. Thirty isolates (60%) were identified as strong biofilm producers. Biofilm formation was inhibited in all strong biofilm-producing isolates following treatment with the MIC/2 concentration of the <i>L. sakei</i> postbiotic. Application of the postbiotic at the MIC/2 concentration reduced biofilm formation and attenuated QS-regulated virulence traits, including pyocyanin production, exoprotease activity, swimming motility, and rhamnolipid production, in strong biofilm-forming isolates. These findings indicate that <i>L. sakei</i>-derived postbiotic may serve as a promising in vitro anti-virulence candidate against antibiotic-resistant <i>P. aeruginosa</i> by reducing biofilm formation and quorum sensing-related phenotypes. Nevertheless, further chemical, molecular, safety, and in vivo studies are needed to confirm its potential applications.</p>

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Fermented sausage–derived Latilactobacillus sakei postbiotic inhibits biofilm formation and quorum sensing-related virulence in clinical antibiotic-resistant Pseudomonas aeruginosa

  • 期刊论文

  • 发表日期：

    2026年7月27日

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  • Epak Sami Abdulazeez Al-Bayatı,
  • Meryem Burcu Külahcı,
  • Yeşim Yıldız

摘要

A single-center in vitro study was performed using 50 clinically-derived Pseudomonas aeruginosa isolates to evaluate the antimicrobial, antibiofilm, and modulation of quorum sensing (QS)-related phenotypes of a fermented sausage-originated Latilactobacillus sakei postbiotic. A total of 50 antibiotic-resistant clinical P. aeruginosa isolates were evaluated. Thirty isolates (60%) were identified as strong biofilm producers. Biofilm formation was inhibited in all strong biofilm-producing isolates following treatment with the MIC/2 concentration of the L. sakei postbiotic. Application of the postbiotic at the MIC/2 concentration reduced biofilm formation and attenuated QS-regulated virulence traits, including pyocyanin production, exoprotease activity, swimming motility, and rhamnolipid production, in strong biofilm-forming isolates. These findings indicate that L. sakei-derived postbiotic may serve as a promising in vitro anti-virulence candidate against antibiotic-resistant P. aeruginosa by reducing biofilm formation and quorum sensing-related phenotypes. Nevertheless, further chemical, molecular, safety, and in vivo studies are needed to confirm its potential applications.