Scholarlink

<p><i>Pyrus pyrifolia</i> (Asian pear) is widely consumed in East Asia and has reported anti-inflammatory properties, but its molecular mechanisms remain unclear. In this study, we investigated the anti-inflammatory effects of an ethanol extract of <i>P. pyrifolia</i> (Pp-EE) using cellular and animal models. Network pharmacology predicted NF-κB signaling as a major target. In macrophages stimulated with Toll-like receptor ligands, Pp-EE suppressed nitric oxide production, reduced iNOS, IL-6, and COX-2 expression, and inhibited NF-κB activity without cytotoxicity. Mechanistically, Pp-EE attenuated early activation of Src and Syk kinases and inhibited downstream PI3K-AKT-IKK signaling. Molecular docking and cellular thermal shift assays supported interactions between phenolic constituents and these kinases. In vivo, Pp-EE alleviated gastric mucosal injury and reduced neutrophil infiltration in inflammatory models. These findings suggest that <i>P. pyrifolia</i> exerts anti-inflammatory effects through modulation of Src/Syk-mediated NF-κB signaling.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Anti-inflammatory effects of Pyrus pyrifolia extract via modulation of Src/Syk-mediated NF-κB signaling

  • 期刊论文

  • 发表日期：

    2026年7月15日

查看全文
  • Jinghan Su,
  • Lei Huang,
  • Yena Oh,
  • Jianmei Zhang,
  • Long You,
  • Dilda Kaskadamova,
  • Ah Young Cho,
  • Yerkyesh Khamit,
  • Sarah Lee,
  • Byoung-Hee Lee,
  • Eun Sil Kim,
  • Leyi Fu,
  • Tianyi Zhou,
  • Fangfang Wang,
  • Fan Qu,
  • Byong Chul Yoo,
  • Jongsung Lee,
  • Jae Youl Cho

摘要

Pyrus pyrifolia (Asian pear) is widely consumed in East Asia and has reported anti-inflammatory properties, but its molecular mechanisms remain unclear. In this study, we investigated the anti-inflammatory effects of an ethanol extract of P. pyrifolia (Pp-EE) using cellular and animal models. Network pharmacology predicted NF-κB signaling as a major target. In macrophages stimulated with Toll-like receptor ligands, Pp-EE suppressed nitric oxide production, reduced iNOS, IL-6, and COX-2 expression, and inhibited NF-κB activity without cytotoxicity. Mechanistically, Pp-EE attenuated early activation of Src and Syk kinases and inhibited downstream PI3K-AKT-IKK signaling. Molecular docking and cellular thermal shift assays supported interactions between phenolic constituents and these kinases. In vivo, Pp-EE alleviated gastric mucosal injury and reduced neutrophil infiltration in inflammatory models. These findings suggest that P. pyrifolia exerts anti-inflammatory effects through modulation of Src/Syk-mediated NF-κB signaling.