Scholarlink

<p>Vascular remodeling is a key process involved in arterial dysfunction. Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, is emerging as a central mechanism in vascular injury. <i>Chrysanthemum coronarium</i> (CC), a traditional edible plant, is known for its potent antioxidant and anti-inflammatory properties. This study evaluated the vascular protective effects of CC against ferroptosis and inflammation in a carotid artery ligation (CAL) mouse model, focusing on sex-specific responses. CC administration significantly attenuated neointimal hyperplasia by inhibiting cell proliferation in ligated carotid arteries, with more pronounced effects observed in male mice. Additionally, CC markedly suppressed the increase in lipid peroxidation and reversed the decrease in ferroptosis-related markers, including xCT, GPX4, and the transferrin receptor, with stronger ferroptotic signatures evident in male mice. Furthermore, CC supplementation downregulated Ptgs2 and 4-HNE expression, suppressed inflammatory responses, and prevented abnormal vascular smooth muscle cell phenotype switching observed in males. Importantly, CC reduced fibrotic markers, with a significant reduction observed in females. These findings suggest that CC provides vascular protection by targeting ferroptosis, inflammation, and fibrosis in a sex-dependent manner and could be developed as a functional food or nutraceutical for preventing vascular dysfunction.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Chrysanthemum coronarium suppresses ferroptosis-driven vascular hyperplasia following carotid artery ligation in mice

  • 期刊论文

  • 发表日期：

    2026年5月20日

查看全文
  • Jong Min Kim,
  • Yiseul Kim,
  • Hyun-Jin Na,
  • Jin Hee Kim,
  • Sang-Hee Lee,
  • Mi Jeong Sung

摘要

Vascular remodeling is a key process involved in arterial dysfunction. Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, is emerging as a central mechanism in vascular injury. Chrysanthemum coronarium (CC), a traditional edible plant, is known for its potent antioxidant and anti-inflammatory properties. This study evaluated the vascular protective effects of CC against ferroptosis and inflammation in a carotid artery ligation (CAL) mouse model, focusing on sex-specific responses. CC administration significantly attenuated neointimal hyperplasia by inhibiting cell proliferation in ligated carotid arteries, with more pronounced effects observed in male mice. Additionally, CC markedly suppressed the increase in lipid peroxidation and reversed the decrease in ferroptosis-related markers, including xCT, GPX4, and the transferrin receptor, with stronger ferroptotic signatures evident in male mice. Furthermore, CC supplementation downregulated Ptgs2 and 4-HNE expression, suppressed inflammatory responses, and prevented abnormal vascular smooth muscle cell phenotype switching observed in males. Importantly, CC reduced fibrotic markers, with a significant reduction observed in females. These findings suggest that CC provides vascular protection by targeting ferroptosis, inflammation, and fibrosis in a sex-dependent manner and could be developed as a functional food or nutraceutical for preventing vascular dysfunction.