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<p>This study evaluated how secondary coating materials modulate the storage stability of liposomes encapsulating <i>Deinococcus radiodurans</i> extracts. Liposomes prepared with soybean-derived phosphatidylcholine were subsequently coated with different cationic materials via electrostatic deposition. Compared with uncoated liposomes, dual-coated systems exhibited distinct changes in particle size distribution and surface charge, indicating successful multilayer formation. Secondary coating increased encapsulation efficiency from 66.5% in primary liposomes to 87.2 and 92.5% in Eco CAT MB- and chitosan-coated liposomes, respectively. After 28&#xa0;d of storage, chitosan-coated liposomes retained the highest encapsulation efficiency (69.8%) and maintained antioxidant activity more effectively than primary liposomes. These findings demonstrate that coating-layer properties, particularly the polymeric barrier effect of chitosan, play a key role in improving the storage stability of bioactive-loaded liposomes.</p>

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Dual-coating strategies for improving the storage stability of bioactive-loaded liposomes

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Jiseon Lee,
  • Ji-Hyang Kim,
  • Sena Jung,
  • Mi-Jung Choi

摘要

This study evaluated how secondary coating materials modulate the storage stability of liposomes encapsulating Deinococcus radiodurans extracts. Liposomes prepared with soybean-derived phosphatidylcholine were subsequently coated with different cationic materials via electrostatic deposition. Compared with uncoated liposomes, dual-coated systems exhibited distinct changes in particle size distribution and surface charge, indicating successful multilayer formation. Secondary coating increased encapsulation efficiency from 66.5% in primary liposomes to 87.2 and 92.5% in Eco CAT MB- and chitosan-coated liposomes, respectively. After 28 d of storage, chitosan-coated liposomes retained the highest encapsulation efficiency (69.8%) and maintained antioxidant activity more effectively than primary liposomes. These findings demonstrate that coating-layer properties, particularly the polymeric barrier effect of chitosan, play a key role in improving the storage stability of bioactive-loaded liposomes.