Scholarlink

<p>This systematic review and meta-analysis assesses the effects of <i>Lactobacillus plantarum</i>, <i>Lactobacillus fermentum</i>, and <i>Lactococcus lactis</i> on lipid profiles using four major databases, following PRISMA 2020 guidelines. Standardized mean differences (SMDs) were pooled using a random-effects model. A total of 38 studies were included. In animal models, probiotic supplementation was associated with improvements in lipid profiles, reducing triglyceride (TG) (SMD: −&#xa0;1.84), total cholesterol (TC) (SMD: −&#xa0;2.26), and low-density lipoprotein cholesterol (LDL-C) (SMD: −&#xa0;1.89) levels, while increasing high-density lipoprotein cholesterol (HDL-C) levels (SMD: + 1.01; all <i>p</i> &lt; 0.05). Significant heterogeneity was observed (<i>I</i><sup><i>2</i></sup> &gt; 70%); however, the pooled estimates remained robust in sensitivity analyses. Subgroup analysis suggested <i>Lactobacillus plantarum</i> as exhibiting the most consistent lipid-lowering efficacy in preclinical models. In contrast, the pooled clinical data, derived from a limited number of RCTs (n = 4), showed only a modest reduction in TG levels, whereas changes in TC and LDL-C levels were not significant. These results indicate potential probiotic-mediated pathways.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of Lactobacillus plantarum, Lactobacillus fermentum, and Lactococcus lactis supplementation on lipid profiles: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年4月27日

查看全文
  • Sungmin Chung,
  • Yujung Lee,
  • Chaeyhyun Oh,
  • Bogyeong Lee,
  • Hyun Kyung Kim,
  • Sumin Kang,
  • Gwang-woong Go

摘要

This systematic review and meta-analysis assesses the effects of Lactobacillus plantarum, Lactobacillus fermentum, and Lactococcus lactis on lipid profiles using four major databases, following PRISMA 2020 guidelines. Standardized mean differences (SMDs) were pooled using a random-effects model. A total of 38 studies were included. In animal models, probiotic supplementation was associated with improvements in lipid profiles, reducing triglyceride (TG) (SMD: − 1.84), total cholesterol (TC) (SMD: − 2.26), and low-density lipoprotein cholesterol (LDL-C) (SMD: − 1.89) levels, while increasing high-density lipoprotein cholesterol (HDL-C) levels (SMD: + 1.01; all p < 0.05). Significant heterogeneity was observed (I2 > 70%); however, the pooled estimates remained robust in sensitivity analyses. Subgroup analysis suggested Lactobacillus plantarum as exhibiting the most consistent lipid-lowering efficacy in preclinical models. In contrast, the pooled clinical data, derived from a limited number of RCTs (n = 4), showed only a modest reduction in TG levels, whereas changes in TC and LDL-C levels were not significant. These results indicate potential probiotic-mediated pathways.