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<p><i>Indocalamus latifolius</i> (IL), a traditional Chinese food packaging material, possesses bioactive compounds with antioxidant and anti-inflammatory properties. This study investigated IL’s aqueous extract (ILAE) protective effects against acute alcohol intoxication (AAI) and chronic alcoholic gastric injury (AGI). In the AAI model, ILAE enhanced ADH and ALDH activities, reduced intoxication rate, shortened sobering time. In the chronic AGI model, ILAE alleviated gastric injury, increased SOD and PGE2, and decreased MDA, TNF-α, IL-6, IL-8, TGF-β1, and MPO levels. Network pharmacology predicts that the PI3K-Akt pathways is the main protective mechanisms. Molecular docking confirmed strong binding affinities between stigmasterol and key target proteins. Furthermore, ILAE downregulated PI3K, AKT, and NF-κB protein expression in ethanol-induced GES-1 cells. These findings suggest that ILAE protects against AAI and AGI by activating the PI3K/AKT pathway regulate oxidative stress and inflammation. Collectively, ILAE shows promise as a functional food component for preventing alcohol-related disorders.</p>

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Effect of Indocalamus latifolius (Keng) McClure aqueous extract against acute alcohol intoxication and chronic alcoholic gastric injury

  • 期刊论文

  • 发表日期：

    2026年4月6日

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  • Shiwei Zhao,
  • Xiangpei Wang,
  • Hongmei Wu,
  • Xiaofen Li

摘要

Indocalamus latifolius (IL), a traditional Chinese food packaging material, possesses bioactive compounds with antioxidant and anti-inflammatory properties. This study investigated IL’s aqueous extract (ILAE) protective effects against acute alcohol intoxication (AAI) and chronic alcoholic gastric injury (AGI). In the AAI model, ILAE enhanced ADH and ALDH activities, reduced intoxication rate, shortened sobering time. In the chronic AGI model, ILAE alleviated gastric injury, increased SOD and PGE2, and decreased MDA, TNF-α, IL-6, IL-8, TGF-β1, and MPO levels. Network pharmacology predicts that the PI3K-Akt pathways is the main protective mechanisms. Molecular docking confirmed strong binding affinities between stigmasterol and key target proteins. Furthermore, ILAE downregulated PI3K, AKT, and NF-κB protein expression in ethanol-induced GES-1 cells. These findings suggest that ILAE protects against AAI and AGI by activating the PI3K/AKT pathway regulate oxidative stress and inflammation. Collectively, ILAE shows promise as a functional food component for preventing alcohol-related disorders.