Scholarlink

<p>Bridging the compositional gap between infant formula and human breast milk is a key goal in infant nutrition research. This study investigated the impact of enriching skim milk powder (SMP) with 2′-fucosyllactose (2′-FL) alone or combined with 6′-sialyllactose (6′-SL), on immune function and gut microbiota in healthy mice. The supplementation of SMP with 2′-FL was found to enhance natural killer (NK) cell activity and T lymphocyte proliferation, whereas the combined supplementation further augmented NK activity, lymphocyte proliferation, and delayed-type hypersensitivity responses. Both treatments modulated gut microbiota by increasing short-chain fatty acids (SCFAs)-producing genera such as <i>Bacteroides</i>, <i>unclassified_Oscillospiraceae</i>, and <i>Rikenellaceae_RC9_gut_group</i>. Additionally, SCFAs concentrations were elevated, with the highest levels observed in dual-supplementation group. These findings indicated that adding 2′-FL, especially in conjunction with 6′-SL, to SMP improved immune function and beneficially modulates gut microbiota, thereby supporting their potential application in improving the functional and immunological properties of infant formula.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Modulating effects of 2′-fucosyllactose and 6′-sialyllactose supplementation in a nutrient-rich skim milk base on immune function and gut microbiota in healthy mice

  • 期刊论文

  • 发表日期：

    2026年4月3日

查看全文
  • Xiaoying Feng,
  • Xiaojiang Jia,
  • Huidong Huang,
  • Nanjie Jiang,
  • Zhenxia Xu,
  • Xia Xiang,
  • Nan Sheng

摘要

Bridging the compositional gap between infant formula and human breast milk is a key goal in infant nutrition research. This study investigated the impact of enriching skim milk powder (SMP) with 2′-fucosyllactose (2′-FL) alone or combined with 6′-sialyllactose (6′-SL), on immune function and gut microbiota in healthy mice. The supplementation of SMP with 2′-FL was found to enhance natural killer (NK) cell activity and T lymphocyte proliferation, whereas the combined supplementation further augmented NK activity, lymphocyte proliferation, and delayed-type hypersensitivity responses. Both treatments modulated gut microbiota by increasing short-chain fatty acids (SCFAs)-producing genera such as Bacteroides, unclassified_Oscillospiraceae, and Rikenellaceae_RC9_gut_group. Additionally, SCFAs concentrations were elevated, with the highest levels observed in dual-supplementation group. These findings indicated that adding 2′-FL, especially in conjunction with 6′-SL, to SMP improved immune function and beneficially modulates gut microbiota, thereby supporting their potential application in improving the functional and immunological properties of infant formula.

Graphical Abstract