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<p>A comprehensive safety evaluation of <i>P. acidilactici</i> SY23 was conducted to assess its suitability as a probiotic strain with anti-inflammatory potential. Previous studies have reported anti-inflammatory activity of <i>P. acidilactici</i> SY23 in RAW 264.7 cells. In the present study, <i>P. acidilactici</i> SY23 exhibited no mucin degradation, gelatin liquefaction, urease or β-glucuronidase activity, or bile salt deconjugation. Biogenic amines and indoles were not detected, whereas D-lactate was produced at approximately 47&#xa0;mM under the tested conditions. <i>P. acidilactici</i> SY23 also showed no β-hemolytic activity and no cytotoxicity toward Caco-2 cells. Antibiotic susceptibility testing showed that the minimum inhibitory concentrations were below EFSA cut-off values for all tested antibiotics. Whole-genome analysis further confirmed the absence of acquired antibiotic resistance and virulence genes. Collectively, these findings suggest that <i>P. acidilactici</i> SY23 may be a suitable probiotic candidate under the evaluated conditions.</p>

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Comprehensive safety assessment of Pediococcus acidilactici SY23 for potential probiotic use in inflammation management

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Soobin Park,
  • Huijin Jeong,
  • Na-Kyoung Lee,
  • Dae‐Kyung Kang,
  • Hyun‐Dong Paik,
  • Young-Seo Park

摘要

A comprehensive safety evaluation of P. acidilactici SY23 was conducted to assess its suitability as a probiotic strain with anti-inflammatory potential. Previous studies have reported anti-inflammatory activity of P. acidilactici SY23 in RAW 264.7 cells. In the present study, P. acidilactici SY23 exhibited no mucin degradation, gelatin liquefaction, urease or β-glucuronidase activity, or bile salt deconjugation. Biogenic amines and indoles were not detected, whereas D-lactate was produced at approximately 47 mM under the tested conditions. P. acidilactici SY23 also showed no β-hemolytic activity and no cytotoxicity toward Caco-2 cells. Antibiotic susceptibility testing showed that the minimum inhibitory concentrations were below EFSA cut-off values for all tested antibiotics. Whole-genome analysis further confirmed the absence of acquired antibiotic resistance and virulence genes. Collectively, these findings suggest that P. acidilactici SY23 may be a suitable probiotic candidate under the evaluated conditions.