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<p>Sarcopenia remains as incurable condition, characterized by the progressive muscle atrophy, which is particularly prevalent in the elderly and individuals with restricted mobility. Functional foods play a role in preventing muscle loss and maintaining muscle function. Here, we evaluated the first beneficial effect of <i>Schizonepeta tenuifolia</i> flower stalk ethanolic extract (DKB138) on sarcopenia in aged mice and in vitro. UPLC-Q-Tof/MS analysis identified seven components in DKB138. In C2C12 skeletal muscle cells, DKB138 inhibited hydrogen peroxide-induced cell death. In a mouse model, nine-week and 18-month-old C57BL/6J female mice were treated with DKB138 (200&#xa0;mg/kg and 300&#xa0;mg/kg) or OMJ (positive control, 300&#xa0;mg/kg). The DKB138-treated groups exhibited significantly enhanced grip strength, reduced inflammation, and lower serum LDL levels. In conclusion, the present study demonstrated that DKB138 inhibits muscle degradation, reduces inflammation, and improves muscle strength, making it a promising functional food for combating muscle dysfunction in the elderly.</p> Graphical abstract <p></p>

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Schizonepeta tenuifolia extract improves muscle strength in aged female mice via anti-inflammatory effects

  • 期刊论文

  • 发表日期：

    2026年2月19日

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  • Young Sook Kim,
  • Heung Joo Yuk,
  • Dong-Seon Kim

摘要

Sarcopenia remains as incurable condition, characterized by the progressive muscle atrophy, which is particularly prevalent in the elderly and individuals with restricted mobility. Functional foods play a role in preventing muscle loss and maintaining muscle function. Here, we evaluated the first beneficial effect of Schizonepeta tenuifolia flower stalk ethanolic extract (DKB138) on sarcopenia in aged mice and in vitro. UPLC-Q-Tof/MS analysis identified seven components in DKB138. In C2C12 skeletal muscle cells, DKB138 inhibited hydrogen peroxide-induced cell death. In a mouse model, nine-week and 18-month-old C57BL/6J female mice were treated with DKB138 (200 mg/kg and 300 mg/kg) or OMJ (positive control, 300 mg/kg). The DKB138-treated groups exhibited significantly enhanced grip strength, reduced inflammation, and lower serum LDL levels. In conclusion, the present study demonstrated that DKB138 inhibits muscle degradation, reduces inflammation, and improves muscle strength, making it a promising functional food for combating muscle dysfunction in the elderly.

Graphical abstract