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<p><i>Punica granatum</i> L. (pomegranate), abundant in Central Asian, especially Uzbekistan, is valued for its polyphenols and other bioactive compounds. While pomegranate-derived products are popular for health benefits, standardized extracts from arils alone have been underexplored. This study investigated the skin-protective, antioxidant, anti-photoaging, and barrier-enhancing effects of a hot water aril extract (Pg-hWE). LC–MS/MS profiling identified dihydrokaempferol, norkurainol, 2”-O-feruloylaloesin, zivulgarin, baohuoside I, and sanggenon A as key components. Pg-hWE showed strong radical scavenging activity and low cytotoxicity in skin cell lines. It significantly suppressed UVB-induced MMP expression, restored COL1A1 and PIP, reduced α-MSH-induced melanin production, inhibited AGEs accumulation, and alleviated oxidative stress-induced senescence. Pg-hWE also upregulated epidermal barrier and hydration-associated factors under basal and UVB-stimulated conditions. Oral administration in mice improved hydration, reduced skin damage, and preserved skin structure. Overall, Pg-hWE demonstrates potent antioxidant and anti-photoaging properties, supporting its potential use as a functional food ingredient for skin health.</p>

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Hot water extract of Punica granatum L. attenuates UVB-induced skin damage and enhances skin barrier function by regulating MKK–MAPK–AP-1 signaling

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Lei Huang,
  • Jinghan Su,
  • Yerkyesh Khamit,
  • Dilda Kaskadamova,
  • Weizhaole Wei,
  • Yanan Liu,
  • Soo Dong Kim,
  • Ji Hye Kim,
  • Jongsung Lee,
  • Jae Youl Cho

摘要

Punica granatum L. (pomegranate), abundant in Central Asian, especially Uzbekistan, is valued for its polyphenols and other bioactive compounds. While pomegranate-derived products are popular for health benefits, standardized extracts from arils alone have been underexplored. This study investigated the skin-protective, antioxidant, anti-photoaging, and barrier-enhancing effects of a hot water aril extract (Pg-hWE). LC–MS/MS profiling identified dihydrokaempferol, norkurainol, 2”-O-feruloylaloesin, zivulgarin, baohuoside I, and sanggenon A as key components. Pg-hWE showed strong radical scavenging activity and low cytotoxicity in skin cell lines. It significantly suppressed UVB-induced MMP expression, restored COL1A1 and PIP, reduced α-MSH-induced melanin production, inhibited AGEs accumulation, and alleviated oxidative stress-induced senescence. Pg-hWE also upregulated epidermal barrier and hydration-associated factors under basal and UVB-stimulated conditions. Oral administration in mice improved hydration, reduced skin damage, and preserved skin structure. Overall, Pg-hWE demonstrates potent antioxidant and anti-photoaging properties, supporting its potential use as a functional food ingredient for skin health.