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<p>This study investigated the immunomodulatory effects of <i>Bifidobacterium animalis</i> subsp. <i>animalis</i> QC08 on cyclophosphamide (CTX)-induced immunosuppression in male Kunming mice, randomly divided into five groups: normal, control, positive control (levamisole hydrochloride, 40&#xa0;mg/kg), low-dose QC08 (2 × 10<sup>8</sup> CFU/kg), and high-dose QC08 (2 × 10<sup>10</sup> CFU/kg). After 21&#xa0;days of intervention, assessments revealed that both QC08 groups significantly improved body weight, spleen/thymus indices, and histopathological damage in thymus/spleen compared to the model group. Serum pro-inflammatory cytokines (IL-1, TNF-α, IL-6) decreased while anti-inflammatory IL-4 increased. Quantitative real-time PCR of ileal tissue showed upregulated expression of intestinal barrier genes (claudin-1, ZO-1, JAM-A, MUPP1, IKKα, IKKγ) and downregulated inflammatory signaling genes (p50, p52). These results demonstrate that QC08 effectively ameliorates CTX-induced immunosuppression by modulating immune responses and enhancing intestinal barrier integrity, supporting the potential of&#xa0;<i>B. animalis</i>&#xa0;subsp.&#xa0;<i>animalis</i>&#xa0;QC08 for immune-enhancing health food development.</p>

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Immunoregulatory effects of Bifidobacterium animalis subsp. animalis QC08 on cyclophosphamide-induced immunosuppression in mice

  • 期刊论文

  • 发表日期：

    2025年11月17日

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  • Lixuan Ren,
  • Fang Tan,
  • Jung-Hwan Oh,
  • Mi-Geon Jo,
  • Xin Ma,
  • Chang-Suk Kong

摘要

This study investigated the immunomodulatory effects of Bifidobacterium animalis subsp. animalis QC08 on cyclophosphamide (CTX)-induced immunosuppression in male Kunming mice, randomly divided into five groups: normal, control, positive control (levamisole hydrochloride, 40 mg/kg), low-dose QC08 (2 × 108 CFU/kg), and high-dose QC08 (2 × 1010 CFU/kg). After 21 days of intervention, assessments revealed that both QC08 groups significantly improved body weight, spleen/thymus indices, and histopathological damage in thymus/spleen compared to the model group. Serum pro-inflammatory cytokines (IL-1, TNF-α, IL-6) decreased while anti-inflammatory IL-4 increased. Quantitative real-time PCR of ileal tissue showed upregulated expression of intestinal barrier genes (claudin-1, ZO-1, JAM-A, MUPP1, IKKα, IKKγ) and downregulated inflammatory signaling genes (p50, p52). These results demonstrate that QC08 effectively ameliorates CTX-induced immunosuppression by modulating immune responses and enhancing intestinal barrier integrity, supporting the potential of B. animalis subsp. animalis QC08 for immune-enhancing health food development.