Scholarlink

<p>Hair loss, marked by thinning hair, reduced density, and increased scalp visibility, is a growing concern. The hair growth cycle is regulated by a dynamic balance between stimulatory growth and inhibitory cytokines. While placenta extracts have demonstrated regenerative, anti-aging, and immunomodulatory effects, their potential role in promoting hair follicle regeneration remains largely unexplored. This study investigated the effects of low molecular weight porcine placenta peptides (Placenderm®) on hair growth. In hDPCs, Placenderm® enhanced cell proliferation and modulated gene expression by upregulating growth-promoting markers and downregulating inhibitory markers. In C57BL/6 mice model, administration of Placenderm® accelerated hair regrowth, prolonged the anagen phase, and led to notable improvements in hair follicle number, size, thickness, and luster. These findings suggest that Placenderm® promotes follicular regeneration by restoring the balance between growth factors and inhibitory cytokines, highlighting its potential as a safe and effective functional food ingredient for hair health applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Low molecular weight porcine placenta peptide (Placenderm®) as a functional ingredient for hair health: evidence from in vitro and in vivo studies

  • 期刊论文

  • 发表日期：

    2025年9月7日

查看全文
  • Chaerin Lee,
  • Jamyeong Koo,
  • Jinhak Kim,
  • Yuri Gwon,
  • Wonchul Lim,
  • Tae-Gyu Lim

摘要

Hair loss, marked by thinning hair, reduced density, and increased scalp visibility, is a growing concern. The hair growth cycle is regulated by a dynamic balance between stimulatory growth and inhibitory cytokines. While placenta extracts have demonstrated regenerative, anti-aging, and immunomodulatory effects, their potential role in promoting hair follicle regeneration remains largely unexplored. This study investigated the effects of low molecular weight porcine placenta peptides (Placenderm®) on hair growth. In hDPCs, Placenderm® enhanced cell proliferation and modulated gene expression by upregulating growth-promoting markers and downregulating inhibitory markers. In C57BL/6 mice model, administration of Placenderm® accelerated hair regrowth, prolonged the anagen phase, and led to notable improvements in hair follicle number, size, thickness, and luster. These findings suggest that Placenderm® promotes follicular regeneration by restoring the balance between growth factors and inhibitory cytokines, highlighting its potential as a safe and effective functional food ingredient for hair health applications.