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<p>Skeletal muscle health is essential for both structural and metabolic functions, making muscle atrophy – the loss of muscle mass – a severe health concern. This study evaluates the potential of <i>Rosa rugosa</i>, an edible plant, to enhance muscle hypertrophy and mitigate muscle atrophy in C2C12 myoblasts. Treatment of <i>Rosa rugosa</i> extract (RRE) promoted myogenic differentiation, as evidenced by morphological changes and upregulation of key myogenic regulatory factors critical for muscle formation. Additionally, RRE activated protein synthesis pathways while suppressing protein degradation pathways. In an inflammatory cytokine-induced muscle atrophy model, RRE preserved myogenic differentiation and inhibited protein breakdown. These findings suggest that RRE fosters an anabolic environment conducive to muscle preservation, underscoring its promise as a functional food ingredient for supporting muscle health.</p>

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Rosa rugosa promotes muscle hypertrophy and prevents atrophy in C2C12 myoblasts

  • 期刊论文

  • 发表日期：

    2024年12月31日

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  • Heeju Kim,
  • Hye In Nam,
  • Chae Won Yoon,
  • Eun Seok Oh,
  • Seungki Lee,
  • Eun Sil Kim,
  • Youn Kyoung Son,
  • Kyung Jin Lee,
  • Sanguine Byun

摘要

Skeletal muscle health is essential for both structural and metabolic functions, making muscle atrophy – the loss of muscle mass – a severe health concern. This study evaluates the potential of Rosa rugosa, an edible plant, to enhance muscle hypertrophy and mitigate muscle atrophy in C2C12 myoblasts. Treatment of Rosa rugosa extract (RRE) promoted myogenic differentiation, as evidenced by morphological changes and upregulation of key myogenic regulatory factors critical for muscle formation. Additionally, RRE activated protein synthesis pathways while suppressing protein degradation pathways. In an inflammatory cytokine-induced muscle atrophy model, RRE preserved myogenic differentiation and inhibited protein breakdown. These findings suggest that RRE fosters an anabolic environment conducive to muscle preservation, underscoring its promise as a functional food ingredient for supporting muscle health.