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<p>This study investigated the anticancer effects of purple carrot extract (PCE) and its key bioactive substance, chlorogenic acid (CHA), on MDA-MB-231 cells and elucidated the mechanisms of apoptosis and anticancer activity. The effects of CHA treatment on the growth of HEK-293 and MDA-MB-231 cells were assessed, and CHA selectively inhibited the growth of MDA-MB-231, indicating specific inhibitory effect on breast cancer. When PCE and CHA were treated to MDA-MB-231 cells, an increase in in the expression of apoptosis-related genes and proteins, including <i>Bcl-2</i>-associated x (<i>Bax</i>), and <i>caspase-9</i>, while the expression of B-cell lymphoma-2 (<i>Bcl-2</i>) decreased (<i>p</i> &lt; 0.05). In conclusion, the study substantiates the potential of CHA, a key bioactive substance in PCE, as a potent anticancer agent, highlighting its superior efficacy in inhibiting breast cancer cell growth through the regulation of apoptosis-related genes and protein expression.</p>

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Anticancer effects of purple carrot extract via induction of apoptotic genes on human breast cancer cells

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Ha Young Park,
  • Sunhye Lee,
  • So Hee Kim,
  • Jung Eun Park,
  • Youn Seon Hwang,
  • Min Ho Kang,
  • Seo Yeon Chae,
  • Jin Woo Kim

摘要

This study investigated the anticancer effects of purple carrot extract (PCE) and its key bioactive substance, chlorogenic acid (CHA), on MDA-MB-231 cells and elucidated the mechanisms of apoptosis and anticancer activity. The effects of CHA treatment on the growth of HEK-293 and MDA-MB-231 cells were assessed, and CHA selectively inhibited the growth of MDA-MB-231, indicating specific inhibitory effect on breast cancer. When PCE and CHA were treated to MDA-MB-231 cells, an increase in in the expression of apoptosis-related genes and proteins, including Bcl-2-associated x (Bax), and caspase-9, while the expression of B-cell lymphoma-2 (Bcl-2) decreased (p < 0.05). In conclusion, the study substantiates the potential of CHA, a key bioactive substance in PCE, as a potent anticancer agent, highlighting its superior efficacy in inhibiting breast cancer cell growth through the regulation of apoptosis-related genes and protein expression.