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Introduction/Objective <p>Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) have an increased risk of developing lung cancer (LC).This study investigated whether non-receipt of immunosuppressive therapy is associated with LC risk in CTD-ILD patients and identified associated risk factors.</p> Methods <p>This retrospective study reviewed 262 patients with CTD-ILD. Patients were divided into an LC group (<i>n</i> = 29) and non-LC group (<i>n</i> = 233). Logistic regression identified risk factors for LC.</p> Results <p>Non-receipt of corticosteroids and/or immunosuppressants (OR 6.675; 95%CI 2.000–22.272; <i>P</i> = 0.002) and usual interstitial pneumonia (UIP) pattern (OR 2.845; 95% CI 1.077–7.519; <i>P</i> = 0.035) were independent risk factors for LC. Most LC patients were stage IV (58.6%). Patients with LC had significantly poorer survival than those without (median 22.3 vs. 168.9&#xa0;months; HR 11.392; 95% CI 6.163–21.057; <i>p</i> &lt; 0.001).</p> Conclusions <p>Non-receipt of immunosuppressive therapy and UIP pattern are independently associated with LC risk in CTD-ILD. The poor prognosis and advanced stage at diagnosis emphasize the need for early LC detection.</p> <p><Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec colname="c1" colnum="1" /> <colspec colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> <p><b>Key Points</b></p> <p>• <i>The UIP pattern and non-receipt of immunosuppressive therapy were independently associated with LC risk, although these findings are not causal.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

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Clinical characteristics of lung cancer in patients with connective tissue disease associated interstitial lung disease: a brief report

  • 期刊论文

  • 发表日期：

    2026年6月26日

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  • Guohua Zhang,
  • Lingling Zhang,
  • Minna Jiang,
  • Yawen Shen,
  • Junli Luo,
  • Yuhua Wang

摘要

Introduction/Objective

Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) have an increased risk of developing lung cancer (LC).This study investigated whether non-receipt of immunosuppressive therapy is associated with LC risk in CTD-ILD patients and identified associated risk factors.

Methods

This retrospective study reviewed 262 patients with CTD-ILD. Patients were divided into an LC group (n = 29) and non-LC group (n = 233). Logistic regression identified risk factors for LC.

Results

Non-receipt of corticosteroids and/or immunosuppressants (OR 6.675; 95%CI 2.000–22.272; P = 0.002) and usual interstitial pneumonia (UIP) pattern (OR 2.845; 95% CI 1.077–7.519; P = 0.035) were independent risk factors for LC. Most LC patients were stage IV (58.6%). Patients with LC had significantly poorer survival than those without (median 22.3 vs. 168.9 months; HR 11.392; 95% CI 6.163–21.057; p < 0.001).

Conclusions

Non-receipt of immunosuppressive therapy and UIP pattern are independently associated with LC risk in CTD-ILD. The poor prognosis and advanced stage at diagnosis emphasize the need for early LC detection.

Key Points

• The UIP pattern and non-receipt of immunosuppressive therapy were independently associated with LC risk, although these findings are not causal.