Aim This study investigated the independent and combined effects of the triglyceride glucose (TyG) index and high-sensitivity C-reactive protein (hsCRP) levels on hyperuricemia (HUA), aiming to provide a scientific basis for early identification and intervention. Methods Participants were categorized into four groups based on the median TyG index (8.66) and the established clinical cutoff for hsCRP (1 mg/L). Restricted cubic spline (RCS) model was employed to test for nonlinear trends between HUA and both the TyG index and hsCRP levels separately. A multivariable logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for HUA across the TyG-hsCRP groups, with the low TyG/low hsCRP group serving as the reference. Results The study included 5,303 participants with a mean age of 49.31 ± 12.13 years, of whom 3,063 (57.76%) were male. RCS model analysis revealed a linear association between the TyG index and HUA (P-nonlinear = 0.52), while hsCRP demonstrated a nonlinear association with HUA (P-nonlinear = 0.01). Multivariable logistic regression demonstrated that compared to the reference group (TyG < 8.66 and hsCRP < 1 mg/L), the risk of HUA increased progressively across exposure groups. The highest risk was observed in participants with combined elevation of both markers (OR = 2.25; 95% CI: 1.69-3.00). Subgroup analyses confirmed this association pattern, particularly demonstrating significant joint associations in women and individuals aged < 65 years. Conclusion The combined elevation of both TyG index and hsCRP levels significantly increases the risk of hyperuricemia, demonstrating a clinically meaningful compound association. This association supports the utility of dual-marker assessment for precise early screening and improved risk stratification.<Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> Key Points • Elevated TyG index and increased hsCRP levels jointly exhibit a significant combined association, correlating with the risk of hyperuricemia (OR = 2.25), suggesting that combined assessment of these two markers in clinical practice may more effectively identify high-risk individuals than evaluating either marker alone. • The TyG index exhibits a linear correlation with risk, whereas hsCRP shows a nonlinear association, suggesting that the two may participate in disease development through distinct mechanisms. This provides clues for exploring differentiated intervention targets. • The combined effect is particularly pronounced in women and individuals under 65 years of age. In clinical screening, dual-marker combined testing can be prioritized for specific populations to achieve more precise early prevention. </entry> </row> </tbody> </tgroup> </Table>

The joint associations of TyG index and hsCRP with hyperuricemia among Chinese adults: a cross-sectional study

期刊论文
发表日期：

2026年2月26日

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Xinru Wang,
Huan Wu,
Lu Zhou,
Errui Song,
Tao Wu,
Ezeokafor Catherine Adaeze,
Yue Wu,
Xinyu Ma,
Tong Wang,
Linsheng Yang,
Yufeng Wen

摘要

Aim

This study investigated the independent and combined effects of the triglyceride glucose (TyG) index and high-sensitivity C-reactive protein (hsCRP) levels on hyperuricemia (HUA), aiming to provide a scientific basis for early identification and intervention.

Methods

Participants were categorized into four groups based on the median TyG index (8.66) and the established clinical cutoff for hsCRP (1 mg/L). Restricted cubic spline (RCS) model was employed to test for nonlinear trends between HUA and both the TyG index and hsCRP levels separately. A multivariable logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for HUA across the TyG-hsCRP groups, with the low TyG/low hsCRP group serving as the reference.

Results

The study included 5,303 participants with a mean age of 49.31 ± 12.13 years, of whom 3,063 (57.76%) were male. RCS model analysis revealed a linear association between the TyG index and HUA (P_-nonlinear = 0.52), while hsCRP demonstrated a nonlinear association with HUA (P_-nonlinear = 0.01). Multivariable logistic regression demonstrated that compared to the reference group (TyG < 8.66 and hsCRP < 1 mg/L), the risk of HUA increased progressively across exposure groups. The highest risk was observed in participants with combined elevation of both markers (OR = 2.25; 95% CI: 1.69-3.00). Subgroup analyses confirmed this association pattern, particularly demonstrating significant joint associations in women and individuals aged < 65 years.

Conclusion

The combined elevation of both TyG index and hsCRP levels significantly increases the risk of hyperuricemia, demonstrating a clinically meaningful compound association. This association supports the utility of dual-marker assessment for precise early screening and improved risk stratification.

Key Points

• Elevated TyG index and increased hsCRP levels jointly exhibit a significant combined association, correlating with the risk of hyperuricemia (OR = 2.25), suggesting that combined assessment of these two markers in clinical practice may more effectively identify high-risk individuals than evaluating either marker alone.

• The TyG index exhibits a linear correlation with risk, whereas hsCRP shows a nonlinear association, suggesting that the two may participate in disease development through distinct mechanisms. This provides clues for exploring differentiated intervention targets.

• The combined effect is particularly pronounced in women and individuals under 65 years of age. In clinical screening, dual-marker combined testing can be prioritized for specific populations to achieve more precise early prevention.