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Background <p>Previous studies have suggested that granulocyte colony-stimulating factor (G-CSF) treatment may trigger large vessel vasculitis (LVV). However, the role of G-CSF in Takayasu arteritis (TAK), a form of LVV, remains unclear. This study aims to investigate the potential role of G-CSF in TAK.</p> Methods <p>This cross-sectional study included 40 TAK patients who met the 1990 American College of Rheumatology (ACR) classification criteria for Takayasu arteritis and 27 healthy controls (HCs). Group differences and correlations between G-CSF level, clinical parameters, and cytokine profiles were analyzed using appropriate tests. Aortic tissues from TAK patients were also examined for G-CSF expression using immunohistochemistry.</p> Results <p>G-CSF levels were significantly higher in TAK patients compared to controls (<i>p</i> &lt; 0.0001), but no difference was found between active and inactive TAK. G-CSF levels positively correlated with neutrophil (<i>R</i> = 0.350, <i>p</i> = 0.028) and platelet counts (<i>R</i> = 0.466, <i>p</i> = 0.005). Elevated G-CSF levels were associated with several cytokines, including IL-6 (<i>R</i> = 0.672, <i>p</i> &lt; 0.001), IL-17 (<i>R</i> = 0.692, <i>p</i> &lt; 0.001), and IFN-γ (<i>R</i> = 0.897, <i>p</i> &lt; 0.001).</p> Conclusion <p>G-CSF may contribute to the inflammatory process and pathogenesis of TAK, offering new perspectives for its diagnosis and treatment.<Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> <p><b>Key Points</b></p> <p>•<i> This study systematically evaluated the role of G-CSF in TAK.</i></p> <p>•<i> G-CSF level was significantly higher in TAK patients.</i></p> <p>•<i> G-CSF level was found to have a significant positive correlation with neutrophil and platelet counts, as well as several cytokines in TAK patients.</i></p> <p>•<i> G-CSF may contribute to the TAK process through the PI3 K-Akt pathway.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

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The role of granulocyte colony-stimulating factor in Takayasu arteritis

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Taotao Li,
  • Zixuan Yang,
  • Na Gao,
  • Junming Zhu,
  • Haiou Hu,
  • Zhiyu Qiao,
  • Lili Pan

摘要

Background

Previous studies have suggested that granulocyte colony-stimulating factor (G-CSF) treatment may trigger large vessel vasculitis (LVV). However, the role of G-CSF in Takayasu arteritis (TAK), a form of LVV, remains unclear. This study aims to investigate the potential role of G-CSF in TAK.

Methods

This cross-sectional study included 40 TAK patients who met the 1990 American College of Rheumatology (ACR) classification criteria for Takayasu arteritis and 27 healthy controls (HCs). Group differences and correlations between G-CSF level, clinical parameters, and cytokine profiles were analyzed using appropriate tests. Aortic tissues from TAK patients were also examined for G-CSF expression using immunohistochemistry.

Results

G-CSF levels were significantly higher in TAK patients compared to controls (p < 0.0001), but no difference was found between active and inactive TAK. G-CSF levels positively correlated with neutrophil (R = 0.350, p = 0.028) and platelet counts (R = 0.466, p = 0.005). Elevated G-CSF levels were associated with several cytokines, including IL-6 (R = 0.672, p < 0.001), IL-17 (R = 0.692, p < 0.001), and IFN-γ (R = 0.897, p < 0.001).

Conclusion

G-CSF may contribute to the inflammatory process and pathogenesis of TAK, offering new perspectives for its diagnosis and treatment.

Key Points

• This study systematically evaluated the role of G-CSF in TAK.

• G-CSF level was significantly higher in TAK patients.

• G-CSF level was found to have a significant positive correlation with neutrophil and platelet counts, as well as several cytokines in TAK patients.

• G-CSF may contribute to the TAK process through the PI3 K-Akt pathway.