<p>Soil creep is of great significance for high-fill engineering in hilly regions, as foundation settlement is closely related to creep behavior. To explore creep characteristics and mechanisms involving special silty clay in West Henan, China, triaxial creep tests and computed tomography were conducted on silty clay specimens obtained from the area. We conducted multi-loading triaxial creep tests under different compaction degrees and moisture contents. The mesoscopic photographs were processed using Avizo software, and the mesostructural information of soil pores was obtained. Results of the triaxial creep test revealed that increasing compaction or reducing moisture content causes the creep deformation of Western Henan’s silty clay to decrease significantly, and they showed that the long-term strength of soil increases exponentially with increasing compaction degrees and decreases exponentially with increasing moisture content. The mesoscopic analysis showed that the large-size pores are preferentially affected after the start of creep, and gradually transform into small-size pores and ellipsoidal and spherical regular pores. The total number of pores increases, the small-size pores increase sharply, the pore diameter gap decreases, and the pores are gradually regularized. After entering the accelerated creep stage, small-sized pores and regular pores gradually transform into large-sized pores and irregular pores. The development of small-sized pores, the emergence of connectivity, and new pores increase the number of large-sized pores and irregular pores. Stress concentration occurs inside the soil, deformation develops rapidly, and the pores are complicated as a whole.</p>