<p>The southwestern region of country is characterized by its complex topography and high average elevation, with numerous jointed rock slopes. Additionally, the intricate terrain of high-altitude areas frequently results in seismic activity. This paper is based on the #1 tunnel slope project in the region, employing both shake table experiments and numerical simulations to analyze the failure modes of the jointed rock slope under seismic conditions and the stability of the jointed rock slope under different parameters. The integrated evaluation method was used in this paper to evaluate the dynamic stability of the slope, which considered both the seismic permanent displacement method and the Dynamic Strength Reduction Method. The specific conclusions are as follows: (1) The failure process of the jointed rock slopes was categorized into three distinct stages: local shear slip, slip surface formation and complete failure. The failure mode was summarized as shear slip failure occurring along the joint surfaces, accompanied by the collapse of locally fragmented rock masses. (2) the slope angle emerged as a significant factor influencing the failure mode of jointed rock slopes. Larger slope angles, greater joint dip angles and smaller joint spacings correlated with increased failure severity and diminished stability. (3) the maximum permanent displacement is positively correlated with both the slope angle and joint dip angle.</p>