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<p>Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and intellectual disabilities (ID), have seen an increasing prevalence in recent years. Both genetic and environmental factors have been implicated in the pathogenesis of these conditions. One such gene, <i>ZNRF3</i>, plays a pivotal role in regulating neural cell growth and connectivity, with variations in this gene linked to disruptions in neural differentiation and communication. This review synthesizes genetic, molecular, and clinical research to examine the role of <i>ZNRF3</i> in brain development. Furthermore, it explores the impact of prenatal environmental exposures and healthcare policies on diagnostic practices and treatment accessibility. The findings highlight the need for improved genetic screening, early intervention strategies, and policy reforms aimed at facilitating personalized care for individuals affected by <i>ZNRF3</i>-related NDDs.</p>

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ZNRF3 in neurodevelopmental disorders: insights into Wnt signaling and therapeutic potential

  • 期刊论文

  • 发表日期：

    2025年10月2日

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  • Yasmin Yusuf Hussein Dinle,
  • Ruping Liu,
  • Mainak Sengupta,
  • Rakesh Kumar Panjaliya,
  • Parimal Das,
  • Anjana Munshi,
  • Samraggi Chakraborty,
  • Jinghua Li,
  • Baiyu Qi,
  • Zakaria Ahmed Mohamed,
  • Qian Tong,
  • Mingyou Zhang,
  • Jianping Wen,
  • Santasree Banerjee

摘要

Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and intellectual disabilities (ID), have seen an increasing prevalence in recent years. Both genetic and environmental factors have been implicated in the pathogenesis of these conditions. One such gene, ZNRF3, plays a pivotal role in regulating neural cell growth and connectivity, with variations in this gene linked to disruptions in neural differentiation and communication. This review synthesizes genetic, molecular, and clinical research to examine the role of ZNRF3 in brain development. Furthermore, it explores the impact of prenatal environmental exposures and healthcare policies on diagnostic practices and treatment accessibility. The findings highlight the need for improved genetic screening, early intervention strategies, and policy reforms aimed at facilitating personalized care for individuals affected by ZNRF3-related NDDs.