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<p>Surface Plasmon Resonance (SPR) has been of intense interest in biomedical sensing due to its application in single-molecule detection for medical diagnosis. In this work, MATLAB software was used for the quantitative analysis of an SPR structure. The structure consists of a silicon (Si) layer with different thicknesses (2, 4, 6, 8, and 10&#xa0;nm) deposited on top of a 50&#xa0;nm thick gold (Au) layer, which is itself deposited on an N-LASF9 glass prism. Air (<i>n</i> = 1) was used as the sensing medium. Three working wavelengths were used: 500, 600, and 700&#xa0;nm. The purpose of this study is to determine the SPR resonance angle (θ<sub>SPR</sub>) from reflectance and absorption curves plotted as a function of the angle of incidence (θ<sub>incid</sub>). The sensor sensitivity (S) is then determined from the results. The simulations effectively detected alterations in the parameters of reflectance, R<sub>min</sub> (minimum reflectance) and FWH (Full Width at Half). The parameters that yielded a reflectance value of 0.02 were observed at a wavelength of 700&#xa0;nm, with a silicon thickness of 10&#xa0;nm, a gold thickness of 50&#xa0;nm. Additionally, the FWH is the best with a silicon thickness of 10&#xa0;nm, a gold thickness of 50&#xa0;nm and its value is 4.49, the sensitivity reached its maximum value156.25°/RIU when the silicon layer thickness was 10&#xa0;nm and a wavelength of 700&#xa0;nm was used.</p>

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Optimization of silicon thickness and wavelength for high-sensitivity Au/Si Bi-layer SPR biosensors: a MATLAB simulation study

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • Sarah H. Ali,
  • Amel H. Daood,
  • Amel S. Saber,
  • Omer A. Ahmad,
  • Hiyam F. Kadem

摘要

Surface Plasmon Resonance (SPR) has been of intense interest in biomedical sensing due to its application in single-molecule detection for medical diagnosis. In this work, MATLAB software was used for the quantitative analysis of an SPR structure. The structure consists of a silicon (Si) layer with different thicknesses (2, 4, 6, 8, and 10 nm) deposited on top of a 50 nm thick gold (Au) layer, which is itself deposited on an N-LASF9 glass prism. Air (n = 1) was used as the sensing medium. Three working wavelengths were used: 500, 600, and 700 nm. The purpose of this study is to determine the SPR resonance angle (θSPR) from reflectance and absorption curves plotted as a function of the angle of incidence (θincid). The sensor sensitivity (S) is then determined from the results. The simulations effectively detected alterations in the parameters of reflectance, Rmin (minimum reflectance) and FWH (Full Width at Half). The parameters that yielded a reflectance value of 0.02 were observed at a wavelength of 700 nm, with a silicon thickness of 10 nm, a gold thickness of 50 nm. Additionally, the FWH is the best with a silicon thickness of 10 nm, a gold thickness of 50 nm and its value is 4.49, the sensitivity reached its maximum value156.25°/RIU when the silicon layer thickness was 10 nm and a wavelength of 700 nm was used.