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<p>This study proposes a compact, low-cost near-infrared fundus imaging system that addresses the limitations of conventional large and expensive devices, enabling non-invasive and non-mydriatic retinal evaluation. Retinal videos were acquired using a monochrome camera, followed by motion correction based on template matching, and vessel enhancement using an isotropic wavelet transform. Time-series changes in vessel diameter, arteriovenous ratio (AVR), and pulse waveforms were extracted from time-series changes in vessel diameter. The acquired images enabled clear visualization of retinal structures, such as the optic disc and blood vessels, and the measured AVR values ranged from 0.67 to 0.88 across five healthy participants. Furthermore, the retinal pulse waveforms showed a weak correlation with the average inter-peak intervals of the fingertip photoplethysmography signals, suggesting the system can capture cardiac-induced periodicity. These preliminary findings also suggest that the system has potential for extracting physiological information. Unlike conventional large and expensive devices using visible light, the proposed system offers a less burdensome, non-invasive alternative suitable for home-based applications. In future work, we aim to increase the number of participants and conduct more clinically oriented studies to validate the system.</p>

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A study on dynamic retinal vessel evaluation using a compact near-infrared fundus imaging system

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月6日

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  • Masaya Kinefuchi,
  • Norio Iijima,
  • Hironari Takehara,
  • Jun Ohta,
  • Naoto Hara,
  • Yasuaki Kamata,
  • Chawan Koopipat,
  • Masato Takahashi,
  • Norimichi Tsumura

摘要

This study proposes a compact, low-cost near-infrared fundus imaging system that addresses the limitations of conventional large and expensive devices, enabling non-invasive and non-mydriatic retinal evaluation. Retinal videos were acquired using a monochrome camera, followed by motion correction based on template matching, and vessel enhancement using an isotropic wavelet transform. Time-series changes in vessel diameter, arteriovenous ratio (AVR), and pulse waveforms were extracted from time-series changes in vessel diameter. The acquired images enabled clear visualization of retinal structures, such as the optic disc and blood vessels, and the measured AVR values ranged from 0.67 to 0.88 across five healthy participants. Furthermore, the retinal pulse waveforms showed a weak correlation with the average inter-peak intervals of the fingertip photoplethysmography signals, suggesting the system can capture cardiac-induced periodicity. These preliminary findings also suggest that the system has potential for extracting physiological information. Unlike conventional large and expensive devices using visible light, the proposed system offers a less burdensome, non-invasive alternative suitable for home-based applications. In future work, we aim to increase the number of participants and conduct more clinically oriented studies to validate the system.