The k-Pell sequence is a generalization of the classical Pell sequence obtained by extending the order of its defining linear recurrence from the second order to an arbitrary order \(k \ge 2\) . Motivated by the works of Gómez and Luca (Glas. Mat. III 50, 17–24, 2015; Math. Slovaca 68, 939–949, 2018) on Diophantine quadruples with values in generalized Fibonacci sequences, we investigate whether there exist quadruples of positive integers \(a_1<a_2<a_3<a_4\) such that all pairwise products \(a_ia_j+1\) (for \(i\ne j\) ) belong to the k-Pell sequence for any \(k\ge 2\) . In this paper, we prove that no such Diophantine quadruples exist, thus showing that there are no Diophantine quadruples with values in the k-Pell sequence for any \(k\ge 2\) .