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<p>In this research, a material composed of HNb<sub>3</sub>O<sub>8</sub> nanosheets, reduced graphene oxide (rGO), polyaniline (PANI) and gold nanoparticles (Au) was prepared and used for glassy carbon electrode (GCE) decoration. After modification, the electrode was then applied to detect dopamine (DA), as well as another biomolecular uric acid (UA). Optimal buffer pH values for individual determination were separately investigated. The sensor based on the modified GCE exhibited low detection limits in simultaneous detection, and the linear ranges were also wide. In individual detection, the detection limits were even lower. Meanwhile, the linear ranges also became wider. The sensor also demonstrated good anti-interference ability, repeatability, reproducibility. The stability was also long when detecting DA and UA. In practical sample detection, the results achieved by the sensor were satisfactory. This work not only provided new possible strategy for fast clinical detection of DA and UA but also found new application for composites of layered materials and graphene.</p>

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An electrochemical sensor based on a quaternary composite of HNb3O8 nanosheets/graphene/polyaniline/gold modified electrode to fast detection of dopamine and uric acid

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Yuge Liu,
  • Guohua Zhou,
  • Zhiguo Li,
  • Yongmei Jia,
  • Jing Chen

摘要

In this research, a material composed of HNb3O8 nanosheets, reduced graphene oxide (rGO), polyaniline (PANI) and gold nanoparticles (Au) was prepared and used for glassy carbon electrode (GCE) decoration. After modification, the electrode was then applied to detect dopamine (DA), as well as another biomolecular uric acid (UA). Optimal buffer pH values for individual determination were separately investigated. The sensor based on the modified GCE exhibited low detection limits in simultaneous detection, and the linear ranges were also wide. In individual detection, the detection limits were even lower. Meanwhile, the linear ranges also became wider. The sensor also demonstrated good anti-interference ability, repeatability, reproducibility. The stability was also long when detecting DA and UA. In practical sample detection, the results achieved by the sensor were satisfactory. This work not only provided new possible strategy for fast clinical detection of DA and UA but also found new application for composites of layered materials and graphene.