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<p>We described the development of an electroanalytical sensor that uses a glassy carbon electrode (GCE) modified by a copper oxide–single-walled carbon nanotube (CuO/SWCNT) nanohybrid for the ultrasensitive and selective measurement of L-tyrosine, a clinically significant biomolecule linked to human health, disease diagnosis, and medical analysis. An increased electrochemical responsiveness and improved interfacial electron mobility resulted from the designed nanointerface’s, due to the synergistic exploitation of the redox-active surface states of CuO and the remarkable charge transport kinetics, aspect ratio, and π-conjugated architecture of SWCNTs. Cyclic voltammetric studies recorded in 0.1&#xa0;M phosphate-buffered solution (PBS, pH 7.0) showed a concentration-dependent anodic peak current with good linearity in the range of 20–200 µM L-tyrosine. A diffusion-controlled electrooxidation process was further clarified by scan rate-dependent investigations. This new sensor demonstrated excellent electrochemical resilience, repeatability, and signal integrity, highlighting its usefulness for accurate biomolecular diagnostics. This work highlights the potential of transition metal oxide–SWCNT composite as sophisticated transduction matrices for electrochemical sensing devices which can be used in the pharmaceutical and therapeutic fields.</p>

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Development of a hybrid nanomaterial-based electrochemical sensor for the determination of L-tyrosine using copper oxide and SWCNTs

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Shalini Nareshkumar,
  • Keerthana Madhivanan,
  • Ashok K. Sundramoorthy

摘要

We described the development of an electroanalytical sensor that uses a glassy carbon electrode (GCE) modified by a copper oxide–single-walled carbon nanotube (CuO/SWCNT) nanohybrid for the ultrasensitive and selective measurement of L-tyrosine, a clinically significant biomolecule linked to human health, disease diagnosis, and medical analysis. An increased electrochemical responsiveness and improved interfacial electron mobility resulted from the designed nanointerface’s, due to the synergistic exploitation of the redox-active surface states of CuO and the remarkable charge transport kinetics, aspect ratio, and π-conjugated architecture of SWCNTs. Cyclic voltammetric studies recorded in 0.1 M phosphate-buffered solution (PBS, pH 7.0) showed a concentration-dependent anodic peak current with good linearity in the range of 20–200 µM L-tyrosine. A diffusion-controlled electrooxidation process was further clarified by scan rate-dependent investigations. This new sensor demonstrated excellent electrochemical resilience, repeatability, and signal integrity, highlighting its usefulness for accurate biomolecular diagnostics. This work highlights the potential of transition metal oxide–SWCNT composite as sophisticated transduction matrices for electrochemical sensing devices which can be used in the pharmaceutical and therapeutic fields.