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<p>Effective serum of uric acid (UA) identification aids global health surveillance because it is a critical measure of general wellness. Hence, in this paper, we report poly-(tris-(1,10-phenanthrolinenickel (II)) complex (poly (Ni(phen)<sub>3</sub>) to detect uric acid (UA). The tris – [1,10-phenanthrolinenickel (II)] (Ni(phen)<sub>3</sub>) complex was prepared utilizing a microwave technique, and followed by different analytical techniques were used to confirm the complexformation. Ni(phen)<sub>3</sub> was electrochemically polymerized in the electrochemical investigation on the (GCE) surface and employed as the working electrode for UA sensor. The Ni(phen)<sub>3</sub>/GCE of the anodic peak potential and bare GCE are noticed at + 0.53&#xa0;V and + 0.63&#xa0;V accordingly. The anodic signal appears on the Ni(phen)<sub>3</sub>/GCE at minimal potential with a large peak current. The electrochemical outcomes of UA revealed remarkable sensibility of linear range from. 8 × 10<sup>–9</sup>&#xa0;M to 1.4 × 10<sup>–7</sup>&#xa0;M, with a limit of sensor at 0.042&#xa0;µM. It explains that the electrochemical detection activity of Ni(phen)<sub>3</sub>/GCE is greater than pure GCE. To test the recently developed UA sensor for potential chemical interference using a range of biomolecules, it showed remarkable selectivity in UA identification. Additionally, the Ni(phen)<sub>3</sub>/GCE detector demonstrated outstanding performance in UA content detection in a human urinary sample. The Ni(phen)<sub>3</sub>/GCE detector has also shown outstanding repeatability, reproducibility, and stability in UA estimation. It is expected that this Ni(phen)<sub>3</sub>/GCE would prove to be a successful path towards creating a reliable UA detector.</p>

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Highly selective electrochemical sensor for uric acid with poly(tris1,10-phenanthrolinenickel) complex modified GCE with microwave irradiation method

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • S. Praveen Kumar,
  • Ravi Aswini,
  • R. Suresh,
  • H. Premkumar,
  • V. Chithambaram

摘要

Effective serum of uric acid (UA) identification aids global health surveillance because it is a critical measure of general wellness. Hence, in this paper, we report poly-(tris-(1,10-phenanthrolinenickel (II)) complex (poly (Ni(phen)3) to detect uric acid (UA). The tris – [1,10-phenanthrolinenickel (II)] (Ni(phen)3) complex was prepared utilizing a microwave technique, and followed by different analytical techniques were used to confirm the complexformation. Ni(phen)3 was electrochemically polymerized in the electrochemical investigation on the (GCE) surface and employed as the working electrode for UA sensor. The Ni(phen)3/GCE of the anodic peak potential and bare GCE are noticed at + 0.53 V and + 0.63 V accordingly. The anodic signal appears on the Ni(phen)3/GCE at minimal potential with a large peak current. The electrochemical outcomes of UA revealed remarkable sensibility of linear range from. 8 × 10–9 M to 1.4 × 10–7 M, with a limit of sensor at 0.042 µM. It explains that the electrochemical detection activity of Ni(phen)3/GCE is greater than pure GCE. To test the recently developed UA sensor for potential chemical interference using a range of biomolecules, it showed remarkable selectivity in UA identification. Additionally, the Ni(phen)3/GCE detector demonstrated outstanding performance in UA content detection in a human urinary sample. The Ni(phen)3/GCE detector has also shown outstanding repeatability, reproducibility, and stability in UA estimation. It is expected that this Ni(phen)3/GCE would prove to be a successful path towards creating a reliable UA detector.