All-solid-state fluoxetine-selective microsensor based on molecular imprinted polymer: fluoxetine determination in pharmaceutical samples
摘要
In this study, a new all-solid-state type polyvinylchloride membrane potentiometric microsensor was developed for the determination of fluoxetine in pharmaceutical drugs. The synthesis of the ionophore involved the use of methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a crosslinker, and fluoxetine as a template, resulting in a fluoxetine-imprinted polymer. The prepared polymer was used as an ionophore in the membrane structure of the microsensor to obtain a selective response against fluoxetine molecules. Subsequently, the fluoxetine-selective microsensor's potentiometric performance characteristics were investigated in detail. The microsensor exhibited a super-Nernstian response with a slope of 60.4 ± 0.7 mV per decade (R2: 0.9990) in fluoxetine solutions over the concentration range of 10–6 − 10–2 mol.L−1. The microsensor also exhibited an optimum performance in the pH range of 4.0–7.0. The response time of the developed microsensor was determined to be ≤ 15 s, and the microsensor could be used for six weeks without significant potential divergence. The developed microsensor has been successfully used for fluoxetine determination in pharmaceutical drug samples. The potentiometric results were statistically compared with the UV–Vis spectroscopic results. The obtained results were in good harmony at a confidence level of 95%.