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<p>Antibacterial bioceramic hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) and hydroxyapatite/chitosan/graphene/gentamicin (HAP/CS/Gr/Gent) coatings on titanium substrate, aimed at bone tissue implants, were produced by electrophoretic deposition (EPD) from aqueous suspensions. The formation and growth of the newly formed HAP layer on both HAP/CS/Gent and HAP/CS/Gr/Gent coatings surfaces were investigated in the simulated body fluid (SBF) at 37&#xa0;°C using electrochemical impedance spectroscopy (EIS) and polarization measurements (PDS). The formation and growth of a new HAP layer were supported by results on the increase in coating impedance and coating pore resistance, as well as a decrease in coating capacitance and corrosion current density after 28-day immersion in SBF. The gentamicin release profiles were determined by high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) and were fitted by a novel two-compartment model with general fractional derivative (GFD) of distributed order, as well as Korsmeyer-Peppas, Makoid–Banakar, and Kopcha diffusion models. It has been proved that the proposed two-compartment model with general fractional derivative of distributed order exhibited significantly better fitting with the experimental release profile in respect to other models and enabled the determination of the gentamicin diffusion coefficient over the entire time period.</p> Graphical Abstract <p></p>

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Bioceramic coatings electrodeposited on titanium surface aimed for medical applications

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Vesna Mišković-Stanković,
  • Milena Stevanović,
  • Teodor M. Atanackovic

摘要

Antibacterial bioceramic hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) and hydroxyapatite/chitosan/graphene/gentamicin (HAP/CS/Gr/Gent) coatings on titanium substrate, aimed at bone tissue implants, were produced by electrophoretic deposition (EPD) from aqueous suspensions. The formation and growth of the newly formed HAP layer on both HAP/CS/Gent and HAP/CS/Gr/Gent coatings surfaces were investigated in the simulated body fluid (SBF) at 37 °C using electrochemical impedance spectroscopy (EIS) and polarization measurements (PDS). The formation and growth of a new HAP layer were supported by results on the increase in coating impedance and coating pore resistance, as well as a decrease in coating capacitance and corrosion current density after 28-day immersion in SBF. The gentamicin release profiles were determined by high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) and were fitted by a novel two-compartment model with general fractional derivative (GFD) of distributed order, as well as Korsmeyer-Peppas, Makoid–Banakar, and Kopcha diffusion models. It has been proved that the proposed two-compartment model with general fractional derivative of distributed order exhibited significantly better fitting with the experimental release profile in respect to other models and enabled the determination of the gentamicin diffusion coefficient over the entire time period.

Graphical Abstract