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<p>In this study, for the first time, the electrochemical properties of vindesine (VDS), a vinca alkaloid, were investigated on boron-doped diamond electrode by cyclic voltammetry and square-wave voltammetry techniques. On this electrode surface, vindesine gave two irreversible peaks at approximately + 0.80&#xa0;V and + 1.12&#xa0;V vs. Ag/AgCl with the cyclic voltammetry technique. When the electrode was activated at + 1.5&#xa0;V in a 0.5&#xa0;M H<sub>2</sub>SO<sub>4</sub> medium, the voltammetric signals were enhanced. Using an anodically pretreated boron-doped diamond electrode, square-wave anodic stripping voltammograms were obtained at a deposition potential of 0.0&#xa0;V for 60&#xa0;s in BR buffer (pH 2, with 0.1&#xa0;mM SDS), focusing on two regions within the linear dynamic range of the electroanalytical method developed for VDS. In the first linear dynamic range (6.45&#xa0;nM to 73.2&#xa0;nM), the following relationship between concentration and anodic current was obtained: <i>Ip</i> (μA) = 22.68 <i>C</i> (μM)—0.026, <i>r</i> = 0.999 (<i>n</i> = 5). In the 2nd linear dynamic range (0.0732&#xa0;μM to 0.586&#xa0;μM), the relationship between concentration and anodic current was as follows: <i>Ip</i> (μA) = 10.43 <i>C</i> (μM) + 0.47, <i>r</i> = 0.994 (<i>n</i> = 7). Both linear dynamic ranges correlate well. The limit of detection was calculated to be 1.25&#xa0;nM. At the same time, the applicability of the developed electroanalytical technique for the quantification of vindesine was illustrated for pharmaceutical and urine samples. The results of the voltammetric technique developed for the analysis of VDS in pharmaceutical samples were supported by spectrophotometric results.</p> Graphical abstract <p></p>

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Electrochemical evaluation of vindesine in anionic surfactant-containing electrolyte using an anodically-pretreated boron-doped diamond electrode

  • 期刊论文

  • 发表日期：

    2025年5月28日

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  • Buse Nur Kalkan,
  • Günay Önal,
  • Abdulkadir Levent

摘要

In this study, for the first time, the electrochemical properties of vindesine (VDS), a vinca alkaloid, were investigated on boron-doped diamond electrode by cyclic voltammetry and square-wave voltammetry techniques. On this electrode surface, vindesine gave two irreversible peaks at approximately + 0.80 V and + 1.12 V vs. Ag/AgCl with the cyclic voltammetry technique. When the electrode was activated at + 1.5 V in a 0.5 M H2SO4 medium, the voltammetric signals were enhanced. Using an anodically pretreated boron-doped diamond electrode, square-wave anodic stripping voltammograms were obtained at a deposition potential of 0.0 V for 60 s in BR buffer (pH 2, with 0.1 mM SDS), focusing on two regions within the linear dynamic range of the electroanalytical method developed for VDS. In the first linear dynamic range (6.45 nM to 73.2 nM), the following relationship between concentration and anodic current was obtained: Ip (μA) = 22.68 C (μM)—0.026, r = 0.999 (n = 5). In the 2nd linear dynamic range (0.0732 μM to 0.586 μM), the relationship between concentration and anodic current was as follows: Ip (μA) = 10.43 C (μM) + 0.47, r = 0.994 (n = 7). Both linear dynamic ranges correlate well. The limit of detection was calculated to be 1.25 nM. At the same time, the applicability of the developed electroanalytical technique for the quantification of vindesine was illustrated for pharmaceutical and urine samples. The results of the voltammetric technique developed for the analysis of VDS in pharmaceutical samples were supported by spectrophotometric results.

Graphical abstract