Electrochemical sensor based on covalent organic framework loaded with FeCr₂O₄ nanoparticles for highly sensitive detection of amoxicillin

A novel electrochemical platform based on a covalent organic framework (COF) and FeCr₂O₄ nanoparticles was prepared for sensitive and selective detection of amoxicillin (AMX). The COF was synthesized with 1,3,5-tris(4-aminophenyl) benzene (TAPB) and 2,5-Dimethoxybenzene-1,4-dicarboxaldehyde (DMTP) as precursors. The morphology and structure of the materials were characterized by scanning electron microscopy, Fourier transform spectroscopy, X-ray diffraction, and energy dispersive spectroscopy. Owing to the synergistic effect of the large surface area of TAPB-DMTP-COF material and the high catalytic capacity of FeCr₂O₄ nanoparticles, the sensor exhibits excellent analytical performance for AMX detection. Differential pulse voltammetry (DPV) experiments prove that the sensor owns a wide detection range (1 ~ 40 and 40 ~ 150 μM) and low detection limit (0.3 μM) for AMX. The sensor has good selectivity and reproducibility and also exhibits a good recovery rate in the actual sample analysis.