Purpose <p>This study evaluated the influence of the additive manufacturing (AM) process of titanium implants on bone-implant contact (BIC) and the mechanical properties of peri-implant human bone after eight weeks of healing.</p> Methods <p>Two types of experimental micro-implants were tested: milled implants with treated surface (MT), and implants produced by AM using titanium powder. Fifteen completely edentulous patients received two temporary micro-implants in the posterior maxilla in a split-mouth model. These implants provided support for an immediate interim full prosthesis during the healing phase of conventional implants placed simultaneously. After eight weeks, the micro-implants and surrounding bone tissue were removed using trephine drills and processed for histological and mechanical analysis. Nanohardness and elastic modulus were measured using a Berkovich indenter on a dynamically controlled instrument.</p> Results <p>Statistical analysis was performed using the Mann-Whitney test. Histometric analysis showed a mean bone-implant contact (BIC) rate of 23.12 ± 12.52% in the AM group and 18.39 ± 4.11% in the MT group. Although the AM group exhibited a higher BIC%, the difference was not statistically significant (<i>p</i> &gt; 0.05). No significant differences were observed in the mechanical analysis variables, neither in the peri-implant bone tissue nor on the implant surfaces.</p> Conclusions <p>Within the limitations of this human study, the AM implants did not influence either the mechanical properties of the peri-implant bone or the BIC.</p>