Purpose <p>Effective wound healing and postoperative pain management are critical in oral and maxillofacial surgery, particularly in alveoloplasty. This study evaluates the efficacy of a novel biomaterial in promoting wound healing and reducing postoperative pain following alveoloplasty. By comparing this biomaterial with conventional treatment methods, the study aims to determine its impact on wound healing, pain relief, and rescue medications required post operatively.</p> Materials and methods <p>A bilateral comparison study was conducted with 14 patients undergoing bilateral alveoloplasty. Standard Alveoloplasty procedure was carried out. On one side, novel biomaterial was placed and sutured. After 21 days, alveoplasty was done on the opposite side and novel biomaterial was not used. Post operative wound healing was assessed using Southampton wound healing scale on post-operative day 1 (POD 1), POD 3, POD 7. Pain score and rescue medications required were noted and compared.</p> Results <p>Results indicate that the novel biomaterial significantly enhances wound healing, demonstrating reduced inflammation, accelerated tissue regeneration, and improved epithelialization. Additionally, patients treated with the biomaterial reported lower postoperative pain levels compared to the control group. It was also noticed that the rescue medications required were less when novel biomaterial was used.</p> Conclusion <p>This study provides valuable insights into the role of advanced biomaterials in surgical recovery, emphasizing their potential to improve postoperative outcomes in alveoloplasty. The findings support the integration of this biomaterial into clinical practice, offering a promising alternative for enhanced healing and pain control.</p>