Objective <p>This review aimed to systematically evaluate the impact of orthognathic surgery on oral function-related quality of life, analyzed preoperative and postoperative changes and their influencing factors.</p> Methodology <p>This study follows the PRISMA guidelines and is registered in PROSPERO with the registration number CRD420250651691. Relevant studies were identified through a search of the PubMed, Web of Science, and Google Scholar databases, focusing on those that utilized the Oral Health Impact Profile (OHIP) and the Orthognathic Quality of Life Questionnaire (OQLQ) to assess changes in oral function-related quality of life before and after surgery. The JBI quality assessment tool was used to evaluate the risk of bias in the included studies.</p> Results <p>A total of 17 studies were included, and key indicators were extracted and analyzed. Results indicated that while mild deterioration in oral function might occur in the short term following orthognathic surgery, long-term follow-ups demonstrated significant improvements in oral function, particularly in chewing, speech, and taste. No significant association was found between gender and oral function improvement. Age may influence patients’ subjective perception of oral function improvement, with older patients reporting more positive perceptions of functional improvements.</p> Conclusion <p>This systematic review concludes that orthognathic surgery has a positive impact on oral function-related quality of life, providing important evidence for clinical practice and patient rehabilitation guidance. However, further studies on the long-term effects of orthognathic surgery and more diverse research are needed to validate and refine the current conclusions.</p>