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Purpose <p>The objective of this systematic review was to determine the analgesic efficacy and safety profile of parecoxib in oral surgery.</p> Materials and methods <p>A comprehensive search was conducted in Medline, Scopus, and Embase to locate clinical trials comparing parecoxib with placebo in third molar surgery. The potential for bias in each included study was assessed using the Cochrane Risk of Bias Assessment Tool, and data were extracted on the number of patients experiencing onset of analgesia, the number of patients requiring rescue medication, the overall assessment of the study drugs, and the number of subjects with nausea, dizziness, vomiting, and headache. Statistical analysis was performed using Review Management 5.3 software.</p> Results <p>The results show that patients receiving the 10&#xa0;mg, 20&#xa0;mg, and 40&#xa0;mg doses had better analgesic efficacy compared to those receiving placebo after third molar surgery. Adverse event assessments were similar between the two treatment groups.</p> Conclusion <p>Parenteral parecoxib induces high-potency postoperative analgesia, which is effective in managing common postoperative complications following third molar extraction. Furthermore, NNT values ​​and ranges are provided for the analgesic efficacy variables evaluated in this systematic review, allowing clinicians to make informed decisions if multiple analgesics are available for consultation.</p>

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Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review

  • 期刊论文

  • 发表日期：

    2025年6月17日

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  • Othoniel Hugo Aragon-Martinez,
  • Eduardo Gómez-Sánchez,
  • Ronell Bologna-Molina,
  • Nelly Molina-Frechero,
  • Sandra López-Verdín,
  • Nicolás Serafín-Higuera,
  • Juan Manuel Guzmán-Flores,
  • Maikel Hermida-Rojas,
  • Mario Alberto Isiordia-Espinoza

摘要

Purpose

The objective of this systematic review was to determine the analgesic efficacy and safety profile of parecoxib in oral surgery.

Materials and methods

A comprehensive search was conducted in Medline, Scopus, and Embase to locate clinical trials comparing parecoxib with placebo in third molar surgery. The potential for bias in each included study was assessed using the Cochrane Risk of Bias Assessment Tool, and data were extracted on the number of patients experiencing onset of analgesia, the number of patients requiring rescue medication, the overall assessment of the study drugs, and the number of subjects with nausea, dizziness, vomiting, and headache. Statistical analysis was performed using Review Management 5.3 software.

Results

The results show that patients receiving the 10 mg, 20 mg, and 40 mg doses had better analgesic efficacy compared to those receiving placebo after third molar surgery. Adverse event assessments were similar between the two treatment groups.

Conclusion

Parenteral parecoxib induces high-potency postoperative analgesia, which is effective in managing common postoperative complications following third molar extraction. Furthermore, NNT values ​​and ranges are provided for the analgesic efficacy variables evaluated in this systematic review, allowing clinicians to make informed decisions if multiple analgesics are available for consultation.