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<p>Isolation of microbial species from extreme environments represents a promising strategy for discovering novel antibacterial compounds. In this study, halophilic bacteria isolated from the water and sediments of hypersaline Lake Urmia were screened for antibacterial activity. Molecular identification based on PCR amplification and 16S rRNA gene sequencing confirmed the isolate as a <i>Marinilactibacillus</i> strain closely related to <i>M. piezotolerans</i>. This strain exhibited strong inhibitory effects against <i>Staphylococcus aureus</i> (MIC 25&#xa0;µg·mL⁻<sup>1</sup>), <i>Escherichia coli</i> (MIC 200&#xa0;µg·mL⁻<sup>1</sup>), and five methicillin-resistant <i>S. aureus</i> (MRSA) strains (MIC 25–50&#xa0;µg·mL⁻<sup>1</sup>; inhibition zones 13–18&#xa0;mm). Gas chromatography–mass spectrometry analysis revealed several bioactive secondary metabolites, including Di-n-octyl phthalate, Diisooctyl phthalate, and Bis(2-ethylhexyl) phthalate, which may contribute to the observed antibacterial activity. This is the first report describing a bioactive <i>Marinilactibacillus</i> isolate from Lake Urmia sediments, emphasizing hypersaline environments as valuable reservoirs of halophilic bacteria with potential for producing alternative antimicrobial agents.</p>

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Exploring Marinilactibacillus sp from Lake Urmia as a novel halophilic source of antibacterial bioactive compounds

  • 期刊论文

  • 发表日期：

    2026年1月28日

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  • Shabnam Golbouy Daghdari,
  • Azam Jafari,
  • Hussein Eisazadeh,
  • Amir Tukmechi

摘要

Isolation of microbial species from extreme environments represents a promising strategy for discovering novel antibacterial compounds. In this study, halophilic bacteria isolated from the water and sediments of hypersaline Lake Urmia were screened for antibacterial activity. Molecular identification based on PCR amplification and 16S rRNA gene sequencing confirmed the isolate as a Marinilactibacillus strain closely related to M. piezotolerans. This strain exhibited strong inhibitory effects against Staphylococcus aureus (MIC 25 µg·mL⁻1), Escherichia coli (MIC 200 µg·mL⁻1), and five methicillin-resistant S. aureus (MRSA) strains (MIC 25–50 µg·mL⁻1; inhibition zones 13–18 mm). Gas chromatography–mass spectrometry analysis revealed several bioactive secondary metabolites, including Di-n-octyl phthalate, Diisooctyl phthalate, and Bis(2-ethylhexyl) phthalate, which may contribute to the observed antibacterial activity. This is the first report describing a bioactive Marinilactibacillus isolate from Lake Urmia sediments, emphasizing hypersaline environments as valuable reservoirs of halophilic bacteria with potential for producing alternative antimicrobial agents.