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Objective <p>The aim of this umbrella review was to synthesize evidence on the effects of non-surgical periodontal therapy (NSPT) on cardiovascular biomarkers in adults with periodontitis.</p> Materials and methods <p>Seven databases were searched up to March 2025 (PROSPERO: CRD420250656185). Included studies evaluated the impact of NSPT on cardiovascular biomarkers, including C-reactive protein (CRP), Interleukin-6, Tumor Necrosis Factor-α, lipid profiles (LDL, HDL, total cholesterol, and triglycerides), and vascular function measures (systolic and diastolic blood pressure, and flow-mediated dilation). The GROOVE tool was used to quantify review overlap, AMSTAR2 for methodological quality and GRADE for evidence certainty. Meta-analyses were recalculated using a random-effects model.</p> Results <p>Of 1,525 records screened, 17 systematic reviews met the inclusion criteria. Pooled findings showed NSPT yielded reductions in CRP (–0.58&#xa0;mg/L; 95% CI: − 0.91 to − 0.25), LDL (–0.10 mmol/L; 95% CI: − 0.17 to − 0.04), and increased HDL (0.03 mmol/L; 95% CI: 0.03 to 0.05), while other markers and vascular measures showed inconsistent and low-certainty results. Most evidence was classified as weak (Class IV) or non-significant due to heterogeneity, high risk of bias, and study overlap.</p> Conclusions <p>NSPT is modestly beneficial for CRP, IL-6, HDL, and LDL levels; however, the overall evidence is limited by methodological weaknesses.</p> Clinical relevance <p>NSPT may offer small yet clinically meaningful improvements in systemic cardiovascular risk markers in patients with periodontitis. Coordinated medical–dental care, targeted patient education, and timely delivery of NSPT can be pragmatically integrated to support cardiovascular risk reduction.</p>

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Does non-surgical periodontal therapy improve biomarkers associated with cardiovascular disease? An umbrella review

  • 期刊论文

  • 发表日期：

    2025年12月11日

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  • Raymond Shi,
  • Lisa Jamieson,
  • Sonia Nath

摘要

Objective

The aim of this umbrella review was to synthesize evidence on the effects of non-surgical periodontal therapy (NSPT) on cardiovascular biomarkers in adults with periodontitis.

Materials and methods

Seven databases were searched up to March 2025 (PROSPERO: CRD420250656185). Included studies evaluated the impact of NSPT on cardiovascular biomarkers, including C-reactive protein (CRP), Interleukin-6, Tumor Necrosis Factor-α, lipid profiles (LDL, HDL, total cholesterol, and triglycerides), and vascular function measures (systolic and diastolic blood pressure, and flow-mediated dilation). The GROOVE tool was used to quantify review overlap, AMSTAR2 for methodological quality and GRADE for evidence certainty. Meta-analyses were recalculated using a random-effects model.

Results

Of 1,525 records screened, 17 systematic reviews met the inclusion criteria. Pooled findings showed NSPT yielded reductions in CRP (–0.58 mg/L; 95% CI: − 0.91 to − 0.25), LDL (–0.10 mmol/L; 95% CI: − 0.17 to − 0.04), and increased HDL (0.03 mmol/L; 95% CI: 0.03 to 0.05), while other markers and vascular measures showed inconsistent and low-certainty results. Most evidence was classified as weak (Class IV) or non-significant due to heterogeneity, high risk of bias, and study overlap.

Conclusions

NSPT is modestly beneficial for CRP, IL-6, HDL, and LDL levels; however, the overall evidence is limited by methodological weaknesses.

Clinical relevance

NSPT may offer small yet clinically meaningful improvements in systemic cardiovascular risk markers in patients with periodontitis. Coordinated medical–dental care, targeted patient education, and timely delivery of NSPT can be pragmatically integrated to support cardiovascular risk reduction.